Mechanism of exercise-induced analgesia: what we can learn from physically active animals.
Mechanism of exercise-induced analgesia: what we can learn from physically active animals.
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DOI：
10.1097/pr9.0000000000000850
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发表时间：
2020-09
期刊：
影响因子：
4.8
通讯作者：
Sluka KA
中科院分区：
文献类型：
--
作者：
Lesnak JB;Sluka KA
体力活动通过脊髓上、脊髓和外周机制产生镇痛作用。目前，没有一种运动模式被证明在镇痛效果上上级其他运动模式。体力活动已成为慢性疼痛患者康复治疗的一线治疗方法。然而，研究只是最近才开始阐明运动镇痛的机制。通过对动物模型的研究，运动已被证明可以诱导大脑，脊髓，免疫系统和受伤部位的变化，以预防和减轻疼痛。动物模型还通过不同的运动模式探索了运动的有益效果，包括跑步，游泳和阻力训练。本文从运动方式、运动强度、运动持续时间等方面对运动镇痛的中枢和外周机制进行综述，并对运动镇痛的临床应用进行展望。
Physical activity produces analgesia through supraspinal, spinal, and peripheral mechanisms. Currently, no exercise mode has proven to be superior to others for analgesic effects. Physical activity has become a first-line treatment in rehabilitation settings for individuals with chronic pain. However, research has only recently begun to elucidate the mechanisms of exercise-induced analgesia. Through the study of animal models, exercise has been shown to induce changes in the brain, spinal cord, immune system, and at the site of injury to prevent and reduce pain. Animal models have also explored beneficial effects of exercise through different modes of exercise including running, swimming, and resistance training. This review will discuss the central and peripheral mechanisms of exercise-induced analgesia through different modes, intensity, and duration of exercise as well as clinical applications of exercise with suggestions for future research directions.