Meta- and pooled analyses of the methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and gastric cancer risk:: A Huge-GSEC review
Meta- and pooled analyses of the methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and gastric cancer risk:: A Huge-GSEC review
复制标题
DOI：
10.1093/aje/kwm344
复制
发表时间：
2008-03-01
影响因子：
5
通讯作者：
Taioli, Emanuela
中科院分区：
文献类型：
--
作者：
Boccia, Stefania;Hung, Rayjean;Taioli, Emanuela
亚甲基四氢叶酸还原酶（MTHFR）是叶酸代谢的关键酶，其在胃癌发生发展中的作用存在争议。作者对病例对照研究进行了荟萃分析和个体数据汇总分析，研究了C677 T和A1298 C多态性之间的关联（前者与低叶酸血清水平有关）和胃癌（荟萃分析：C677 T的16项研究，2，727例病例和4，640例对照; A1298 C的7项研究，1，223例病例和2，015例对照;汇总分析：C677 T的9项研究，1，540例病例和2，577例对照; A1298 C的5项研究，1，146例病例和1，549例对照）。在荟萃分析（比值比（OR）1.52，95%置信区间（CI）：1.31，1.77）和汇总分析（OR = 1.49，95% CI：1.14，1.95）中发现MTHFR 677 TT的风险增加。MTHFR 1298 CC无相关性（荟萃OR = 0.94，95% CI：0.65，1.35;汇总OR = 0.90，95% CI：0.69，1.34）。根据叶酸水平分层的4项C677 T研究的汇总分析结果显示，叶酸水平低（OR 2.05，95% CI：1.13，3.72）与叶酸水平高（OR = 0.95，95% CI：0.54，1.67）的个体风险增加。总之，这些发现支持叶酸在胃癌发生中起作用的假设。
Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in the metabolism of folate, whose role in gastric carcinogenesis is controversial. The authors performed a meta-analysis and individual data pooled analysis of case-control studies that examined the association between C677T and A1298C polymorphisms (the former being associated with low folate serum levels) and gastric cancer (meta-analyses: 16 studies, 2,727 cases and 4,640 controls for C677T and seven studies, 1,223 cases and 2,015 controls for A1298C; pooled analyses: nine studies, 1,540 cases and 2,577 controls for C677T and five studies, 1,146 cases and 1,549 controls for A1298C). An increased risk was found for MTHFR 677 TT in the meta-analysis (odds ratio (OR) 1.52, 95% confidence interval (CI): 1.31, 1.77) and pooled analysis (OR = 1.49, 95% CI: 1.14, 1.95). No association resulted for MTHFR 1298 CC (meta-OR = 0.94, 95% CI: 0.65, 1.35; pooled OR = 0.90, 95% CI: 0.69, 1.34). Results from the pooled analysis of four studies on C677T stratified according to folate levels showed an increased risk for individuals with low (OR 2.05, 95% CI: 1.13, 3.72) versus high (OR = 0.95, 95% CI: 0.54, 1.67) folate levels. Overall, these findings support the hypothesis that folate plays a role in gastric carcinogenesis.