Rapid microfluidic mixing
Rapid microfluidic mixing
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DOI：
10.1021/ac010895d
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发表时间：
2002-01-01
影响因子：
7.4
通讯作者：
Locascio, LE
中科院分区：
文献类型：
--
作者：
Johnson, TJ;Ross, D;Locascio, LE
使用脉冲紫外准分子激光（KrF，248 nm）对压印在聚碳酸酯中的预制 T 型微通道进行后修改，以在连接处创建一系列倾斜孔。孔的存在导致通道内的高度横向传输以及经历电渗流的两个汇合流的快速混合。制造并研究了几种混合器设计。所有设计在低流速（0.06 cm/s，大于或等于 75% 混合）下都相对成功，但在高流速（0.81 cm/s，45-80% 混合）下取得了不同程度的成功。例如，一种在高流速下运行的设计能够根据存在的倾斜孔的数量将进入的荧光流分成不同浓度的两股流。最终的混合器设计能够克服高流速下的流分裂问题，并且结果表明，在流速为 0.81 cm/s 的 T 形接头 443 mm 范围内，两股进入的流混合了 80%。在没有混合器的情况下，在相同的高流速下，当完全依靠分子扩散时，需要 2.3 cm 的通道长度才能实现相同程度的混合，而 99% 的混合则需要 6.9 cm 的通道长度。
A preformed T-microchannel imprinted in polycarbonate was postmodified with a pulsed UV excimer laser (KrF, 248 nm) to create a series of slanted wells at the junction. The presence of the wells leads to a high degree of lateral transport within the channel and rapid mixing of two confluent streams undergoing electroosmotic flow. Several mixer designs were fabricated and investigated. All designs were relatively successful at low flow rates (0.06 cm/s, greater than or equal to 75% mixing), but had varying degrees of success at high flow rates (0.81 cm/s, 45-80% mixing). For example, one design operating at high flow rates was able to split an incoming fluorescent stream into two streams of varying concentrations depending on the number of slanted wells present. The final mixer design was able to overcome stream splitting at high flow rates, and it was shown that the two incoming streams were 80% mixed, within 443 mum of the T-junction for a flow rate of 0.81 cm/s. Without the presence of the mixer and at the same high flow rate, a channel length of 2.3 cm would be required to achieve the same extent of mixing when relying upon molecular diffusion entirely, while 6.9 cm would be required for 99% mixing.