HIV-specific CD4 T cells and immune control of viral replication.
HIV-specific CD4 T cells and immune control of viral replication.
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DOI：
10.1097/coh.0b013e3283454058
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发表时间：
2011-05
影响因子：
4.1
通讯作者：
Kaufmann DE
中科院分区：
文献类型：
--
作者：
Porichis F;Kaufmann DE
了解hiv特异性CD4 T细胞在病毒控制中的作用，并强调该领域的最新进展。hiv特异性CD4 T细胞在精英控制者中显示出比进行性感染受试者更高的功能贪婪度。art治疗对象的消化粘膜中hiv特异性CD4 T细胞群出现损耗，这与自发病毒控制个体的强劲反应形成鲜明对比。由hiv特异性CD4 T细胞分泌的细胞因子IL-21与疾病控制有关，并增强hiv特异性CTL抑制病毒复制的能力。对PD-1、IL-10和Tim-3通路的研究提供了对hiv特异性CD4 T细胞耗竭机制的深入了解，并提供了操纵这些网络可能恢复免疫功能的新证据。新型HIV和SIV疫苗可引起稳健的、多功能的CD4 T细胞应答。这些观察结果表明，hiv特异性CD4 T细胞反应在精英控制者和进行性疾病个体中是不同的。有证据表明，艾滋病毒特异性CD4 T细胞将是有效的艾滋病毒疫苗的重要组成部分，需要做出重大努力，进一步了解艾滋病毒特异性CD4 T细胞在不同身体区室中的功能。
To understand the role of HIV-specific CD4 T cells in viral control and highlight recent progress in the field. HIV-specific CD4 T cells show higher functional avidity in elite controllers than in subjects with progressive infection. There is an attrition of the HIV-specific CD4 T cell population in the digestive mucosa of ART-treated subjects that contrasts with robust responses in individuals with spontaneous viral control. Secretion of the cytokine IL-21, by HIV-specific CD4 T cells, is associated with disease control and enhances the capacity of HIV-specific CTL's to suppress viral replication. Studies of the PD-1, IL-10 and Tim-3 pathways provided insight into mechanisms of HIV-specific CD4 T cell exhaustion and new evidence that manipulation of these networks may restore immune functions. Robust, polyfunctional CD4 T cell responses can be elicited with novel HIV and SIV vaccines. These observations show that HIV-specific CD4 T cell responses are different in elite controllers and individuals with progressive disease. Evidence suggests that HIV-specific CD4 T cells will be an important component of an effective HIV vaccine and significant efforts need to be done to further our understanding of HIV-specific CD4 T cell functions in different body compartments.