Benign hereditary chorea as an experimental model to investigate the role of medium spiny neurons for response adaptation
Benign hereditary chorea as an experimental model to investigate the role of medium spiny neurons for response adaptation
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DOI：
10.1016/j.neuropsychologia.2014.05.004
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发表时间：
2014-07-01
期刊：
影响因子：
2.6
通讯作者：
Saft, Carsten
中科院分区：
文献类型：
--
作者：
Beste, Christian;Saft, Carsten
处理错误是行为适应的主要要求。虽然已经假设基底神经节在启动这些过程中发挥了重要作用，但纹状体微结构在这些过程中的作用仍有待揭示。以前的研究在基底神经节疾病不能明确阐明的纹状体中型棘神经元（MSN）的微观结构的相关性，因为结构的改变发生在一起的各种神经递质system.We提出和检查一个可能的模型，允许检查MSN功能障碍公正的其他调制，即“良性遗传性舞蹈病”（BHC）的情况下，与健康对照组相比。我们应用事件相关电位（ERPs）来揭示错误后行为适应的神经生理机制。BHC患者表现出较小的错误相关负性（ERN），错误后几乎没有行为适应，并且通常更容易出错。与错误无关的性能监测过程以及反应抑制过程在BHC患者中不受影响。结果表明，纹状体MSN微结构的完整性是更重要的错误相关的行为适应比其他反应监测过程无关的错误。(C)2014爱思唯尔有限公司版权所有。
Processing errors is a major requirement for behavioral adaptation. While it has been assumed that the basal ganglia play an important role in initiating these processes, the role of the striatal microstructure for these processes remains to be uncovered. Previous studies in basal ganglia diseases could not elucidate the relevance of the striatal medium spiny neuron (MSN) microstructure unambiguously because structural alterations occur together with alterations in various neurotransmitter systems.We present and examine a possible model that allows the examination of MSN dysfunction unbiased by other modulations, i.e. a case of 'benign hereditary chorea' (BHC) in comparison to healthy controls. We apply event-related potentials (ERPs) to uncover the underlying neurophysiological mechanisms underlying post-error behavioral adaptation. The BHC patient revealed a smaller error-related negativity (ERN) together with almost absent behavioral adaptation after an error and generally more error-prone behavior. Performance monitoring processes unrelated to errors, as well as response inhibition processes, were not affected in the BHC patient. The results suggest that the striatal MSN microstructural integrity is more important for error-related behavioral adaptation than for other response monitoring processes unrelated to errors. (C) 2014 Elsevier Ltd. All rights reserved.