Targeted rejection predicts decreased anti-inflammatory gene expression and increased symptom severity in youth with asthma.
Targeted rejection predicts decreased anti-inflammatory gene expression and increased symptom severity in youth with asthma.
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DOI：
10.1177/0956797614556320
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发表时间：
2015-02
影响因子：
8.2
通讯作者：
Miller GE
中科院分区：
文献类型：
--
作者：
Murphy ML;Slavich GM;Chen E;Miller GE
尽管对压力的反应有时被认为在不同的压力源中是相似的，但最近的研究表明，某些类型的压力，如针对性的拒绝，特别有影响力。为了在慢性疾病模型中测试这种关联，我们研究了非人际、人际和靶向排斥生活事件如何预测121名哮喘青年的基因表达和症状严重程度的变化，这些哮喘患者每6个月评估一次，持续2年。最近经历过靶向排斥反应的青少年控制气道炎症和阻塞的信号分子mRNA较少，特别是糖皮质激素受体和β2-肾上腺素能受体。这些关联只针对有针对性的拒绝，对地位较高的年轻人更强。地位较高的青少年暴露于有针对性的排斥（而不是其他类型的压力）也表现出更多的哮喘症状。这些数据表明，压力源特异性与分子信号通路和哮喘疾病严重程度有关，并表明对社会自我的威胁可能特别有害。
Although responses to stress are sometimes assumed to be similar across different stressors, recent research has demonstrated that certain types of stress, such as targeted rejection, are particularly impactful. To test such associations in a chronic disease model, we examined how non-interpersonal, interpersonal, and targeted rejection life events predicted changes in gene expression and symptom severity in 121 youth with asthma who were assessed every 6 months for 2 years. Youth who recently experienced targeted rejection had less mRNA for signaling molecules that control airway inflammation and obstruction, specifically the glucocorticoid receptor and β2-adrenergic receptor. These associations were specific to targeted rejection and stronger for higher-status youth. Higher-status youth exposed to targeted rejection (but not other types of stress) also exhibited more asthma symptoms. These data demonstrate stressor-specific associations with molecular signaling pathways and asthma disease severity, and suggests threats to the social self may be particularly deleterious.
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影响因子：
8.2
作者：
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通讯作者：
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