Spatial memory deficits in patients with unilateral damage to the right hippocampal formation
Spatial memory deficits in patients with unilateral damage to the right hippocampal formation
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DOI：
10.1016/s0028-3932(96)00051-6
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发表时间：
1997-01-01
期刊：
影响因子：
2.6
通讯作者：
Morris, RG
中科院分区：
文献类型：
--
作者：
Abrahams, S;Pickering, A;Morris, RG
对30例顽固性颞叶癫痫(TLE)或47例颞叶切除术(TLR)所致的单侧颞叶损害患者进行了九盒迷宫检查。这项任务类似于放射状手臂迷宫，旨在比较海马体功能的空间映射和工作记忆理论。这项任务提供了空间记忆、客体记忆、工作记忆和参照记忆的测量，并纳入了受试者的设计。空间部分旨在鼓励形成以分配为中心的空间表征，而不是以自我为中心的空间表征。TLE和TLR患者均存在空间记忆缺陷(包括工作记忆和参考记忆)，但在相应的左侧颞叶损害患者中存在完整的空间记忆缺陷。在匹配的非空间(客体)工作记忆成分上，所有组的表现都与健康对照组相同。然而，所有患者组在物体参考记忆上都表现出缺陷。这些发现被讨论与潜在的颞叶病理，特别是海马结构的萎缩。总体而言，这些结果支持了海马区功能的认知图谱理论，证明了右侧海马区受损患者存在选择性(可能是局部中心性)空间记忆缺陷。版权所有(C)1996爱思唯尔科学有限公司。
Patients with unilateral temporal lobe damage resulting from intractable temporal lobe epilepsy (TLE, n = 30) or from temporal lobe resection (temporal lobectomy, TLR, n = 47) were investigated on the Nine-box Maze. The task, analogous to the radial arm maze, was designed to compare spatial mapping and working memory theories of the functions of the hippocampus. The task provides measures of spatial, object, working and reference memory, incorporated into a within subjects design. The spatial component was designed to encourage the formation of allocentric rather than egocentric spatial representations. Spatial memory deficits were found (across working and reference memory components) in both TLE and TLR patients with right temporal lobe damage, with intact spatial memory in patients with corresponding left temporal lobe damage. Performance on the matched nonspatial (object) working memory component was equal to healthy controls for all groups. However all patient groups showed a deficit on object reference memory. These findings are discussed in relation to the underlying temporal lobe pathology and particularly atrophy of the hippocampal formation. Overall, the results support the cognitive mapping theory of hippocampal function, with the demonstration of a selective (and probably allocentric) spatial memory deficit in patients with right hippocampal damage. Copyright (C) 1996 Elsevier Science Ltd.