Release of dopamine and 5-hydroxytryptamine from rat striatal slices following activation of nicotinic cholinergic receptors.
Release of dopamine and 5-hydroxytryptamine from rat striatal slices following activation of nicotinic cholinergic receptors.
复制标题
烟碱胆碱能受体激活后，大鼠纹状体切片释放多巴胺和 5-羟色胺。
DOI：
10.1016/0306-3623(83)90037-x
复制
发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Perry,H
中科院分区：
文献类型：
--
作者：
Westfall,TC;Grant,H;Perry,H
1.应用烟碱类胆碱能激动剂碘化二甲基苯基哌嗪（DMPP）或尼古丁，可引起大鼠纹状体灌流脑片中[~ 3 H]多巴胺、[~ 3 H] 5-羟色胺以及内源性多巴胺和5-羟色胺的浓度依赖性释放。2.释放的标记和非标记的递质拮抗烟碱拮抗剂，六甲铵，但不是毒蕈碱拮抗剂，阿托品。3.本研究提供了额外的证据表明，烟碱胆碱能受体存在于哺乳动物中枢神经系统。4.纹状体中这些烟碱胆碱能受体的激活导致多巴胺和5-羟色胺的释放。
1. The administration of the nicotinic cholinergic agonists dimethylphenylpiperazinium iodide (DMPP) or nicotine caused a concentration dependent release of [3H] dopamine,[3H] 5-hydroxytryptamine as well as endogenous dopamine and 5-hydroxytryptamine from superfused slices of rat striatum. 2. Release of both labelled and non-labelled transmitter was antagonized by the nicotinic antagonist, hexamethonium but not the muscarinic antagonist, atropine. 3. The present study provides additional evidence that nicotinic-cholinergic receptors are present in the mammalian central nervous system. 4. Activation of these nicotinic-cholinergic receptors in the striatum results in the release of both dopamine and 5-hydroxytryptamine.