Intramolecular Heck reactions of unactivated alkyl halides
Intramolecular Heck reactions of unactivated alkyl halides
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DOI：
10.1021/ja075245r
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发表时间：
2007-09-19
影响因子：
15
通讯作者：
Fu, Gregory C.
中科院分区：
文献类型：
--
作者：
Firmansjah, Luke;Fu, Gregory C.
研究了钯催化下未活化的β-含氢烷基溴化物和氯化物的分子内Heck反应。从立体化学研究的数据是一致的，通过烷基钯，而不是自由基，中间体的碳-碳键形成。
A method has been developed for achieving palladium-catalyzed intramolecular Heck reactions of unactivated, beta-hydrogen-containing alkyl bromides and chlorides. The data from a stereochemical investigation are consistent with carbon-carbon bond formation via an alkylpalladium, rather than a radical, intermediate.