A living electrode construct for incorporation of cells into bionic devices
A living electrode construct for incorporation of cells into bionic devices
复制标题
DOI：
10.1557/mrc.2017.44
复制
发表时间：
2017-09-01
影响因子：
1.9
通讯作者：
Green, Rylie
中科院分区：
文献类型：
--
作者：
Goding, Josef;Gilmour, Aaron;Green, Rylie
已经开发了一种能够将细胞整合到仿生装置内的活电极构造。分层结构使用不可降解的导电水凝胶和可降解的生物合成水凝胶的组合来支持装置表面处的细胞包封。在这项研究中，材料系统的设计和分析，以了解电池承载组件对电极特性的影响。细胞承载层被示出为提供支持电极内的细胞外基质发育的软界面，同时不显著降低电荷转移特性。活体层在植入后21天内降解，肿胀最小。
A living electrode construct that enables integration of cells within bionic devices has been developed. The layered construct uses a combination of non-degradable conductive hydrogel and degradable biosynthetic hydrogel to support cell encapsulation at device surfaces. In this study, the material system is designed and analyzed to understand the impact of the cell carrying component on electrode characteristics. The cell carrying layer is shown to provide a soft interface that supports extracellular matrix development within the electrode while not significantly reducing the charge transfer characteristics. The living layer was shown to degrade over 21 days with minimal swelling upon implantation.