Acute disseminated encephalomyelitis: MR Diffusion weighted imaging: Potential diagnostic value and outcome predilection
Acute disseminated encephalomyelitis: MR Diffusion weighted imaging: Potential diagnostic value and outcome predilection
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DOI：
10.1016/j.ejrnm.2017.01.004
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发表时间：
2017-03-01
影响因子：
1
通讯作者：
Abd-Elsalam, Osama Ahmed
中科院分区：
文献类型：
--
作者：
Kamr, Wael Hamza;El-Tantawy, Amir Monier;Abd-Elsalam, Osama Ahmed
急性播散性脑脊髓炎（ADEM）是一种影响中枢神经系统（CNS）的炎性疾病，具有多种和可变的神经系统体征。研究目的：为探讨磁共振弥散成像（MR Diffusion）对急性脑脊髓炎（ADEM）的诊断价值及其预后的影响，采用前瞻性研究方法，对35例ADEM患者进行了详细的病史调查和临床检查，其中23例进行了CT检查，所有病例均行增强MRI和MR Diffusion检查。对所有病例进行了进一步的CSF实验室检查。结果：35例患者中，9例弥散加权像无异常，10例T2穿透，16例弥散受限。在随访中，没有异常扩散或T2穿透效应的患者对药物有反应，并在6个月内显示完全恢复。16例弥散受限患者中，7例在6个月内恢复，9例出现其他发作，随访18个月完全恢复。结论：MR弥散成像对ADEM患者的脑组织改变有很大的帮助，并能预测其病程和转归。(C)2017年埃及放射学与核医学学会。由Elsevier制作和主持。
Acute disseminated encephalomyelitis (ADEM) is an inflammatory disease affecting the central nervous system (CNS) with multiple and variable neurological signs. Aim of the study: To assess the diagnostic value of MR Diffusion in diagnosis of ADEM and its outcome predilection.Patients and method: A prospective study included 35 patients conducted for accurate history taking and meticulous clinical examination, radiological imaging including CT in 23 cases, contrast enhanced MRI and MR Diffusion for all cases. Further CSF laboratory investigations were done for all cases. All patients were followed up after I month from the first presentation, after 6 months, 12 months and after 18 months with repeated MRI examination.Results: Thirty-five patients were included in our study over a period of 3 years; 9 patients with no abnormality in diffusion WI, 10 patients with T2 shine through effect and 16 patients with restricted diffusion. On follow up, patients with no abnormal diffusion or T2 shine through effect respond to medication and shows complete recovery within 6 months. While the other 16 patients with initial restricted diffusion, 7 of them showed recovery within 6 months and other 9 patients showed other attacks and complete recovery on long run follow up till 18 months.Conclusion: MR Diffusion provides a great help in detection of the brain tissue changes in ADEM in addition to the predilection of the course and outcome of the disease. (C) 2017 The Egyptian Society of Radiology and Nuclear Medicine. Production and hosting by Elsevier.