Effects of deoxycorticosterone on arterial wall properties in two-kidney rats.
Effects of deoxycorticosterone on arterial wall properties in two-kidney rats.
复制标题
脱氧皮质酮对两肾大鼠动脉壁特性的影响。
DOI：
10.1097/00004872-198610000-00007
复制
发表时间：
1986
影响因子：
4.9
通讯作者：
Cox,RH
中科院分区：
文献类型：
--
作者：
Cox,RH
在 Wistar 大鼠中评估了醋酸脱氧皮质酮 (DOCA) 和盐对动脉压和高血压相关动脉壁变化的影响。一组接受 DOCA 治疗的两肾动物接受高盐饮食，另一组接受低盐饮食。治疗16周后，与未治疗的对照组相比，低盐摄入的动物的动脉压没有显着升高，而高盐组的血压显着升高。后一组的值不如单肾、高盐 DOCA 处理的动物的值高。颈动脉和尾动脉的片段用于机械和化学研究。使用低盐双肾 DOCA 组的动脉获得的数据与未治疗对照组的数据没有显着差异。与低盐组和未处理的对照组相比，两个高盐组发现了许多显着差异；这些包括心脏肥大、被动动脉僵硬度增加、结缔组织浓度降低以及响应高钾加去甲肾上腺素激活而增加的最大力量发展。与双肾 DOCA 动物相比，单肾动物发生了更大的变化。因此，对高盐摄入的两肾大鼠施用 DOCA 会产生中度动脉高血压和高血压相关的动脉壁变化。另一方面，对低盐摄入量的双肾大鼠施用 DOCA 不会导致动脉压增加，也不会改变动脉壁特性。这些结果表明，在盐过量的情况下，DOCA 不会升高动脉压或产生动脉壁变化。此外，该动物模型中的动脉壁变化可能与动脉压变化的幅度直接相关。
The contribution of deoxycorticosterone acetate (DOCA) and salt to arterial pressure and hypertension-related arterial wall changes was assessed in Wistar rats. One group of two-kidney DOCA-treated animals was given a high salt diet and another group a low salt diet. After 16 weeks of treatment, the animals on low salt intake did not exhibit a significant increase in arterial pressure compared with untreated controls, while pressure was significantly elevated in the high-salt group. Values for the latter group were not as high as values in one-kidney, high salt DOCA-treated animals. Segments of the carotid and tail arteries were used for mechanical and chemical studies. Data obtained using arteries from the low salt two-kidney DOCA group were not significantly different from those of untreated controls. A number of significant differences were found in the two high salt groups compared with the low salt group and untreated controls; these included cardiac hypertrophy, increased passive arterial stiffness, decreased connective tissue concentration and increased maximum force development in response to high potassium plus norepinephrine activation. Larger changes were found in one-kidney compared to two-kidney DOCA animals. Thus DOCA administration to two-kidney rats on high salt intake produces moderate arterial hypertension and hypertension-related arterial wall changes. On the other hand DOCA administration to two-kidney rats on low salt intake does not produce an increase in arterial pressure nor altered arterial wall properties. These results suggest that DOCA in the absence of salt excess does not elevate arterial pressure or produce arterial wall changes. Furthermore, arterial wall changes in this animal model may be directly linked to the magnitude of arterial pressure changes.