Thermoacoustic and photoacoustic tomography of thick biological tissues toward breast imaging
Thermoacoustic and photoacoustic tomography of thick biological tissues toward breast imaging
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DOI：
10.1177/153303460500400509
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发表时间：
2005-10-01
影响因子：
2.8
通讯作者：
Wang, LV
中科院分区：
文献类型：
--
作者：
Ku, G;Fornage, BD;Wang, LV
基于微波的热声层析成像（达特）和基于激光的光声层析成像（PAT）在一个圆形的扫描配置都被开发用于成像深层次的病变和生物组织中的对象。由于恶性乳腺组织比良性乳腺组织更强烈地吸收微波，因此在人类乳腺切除术标本中达特以良好的空间分辨率和对比度对癌症进行成像。基于血液和鸡胸肌肉之间的固有光学对比度，还使用波长为1064 nm的PAT检测到组织中5 cm深的嵌入血液物体。
Microwave-based thermoacoustic tomography (TAT) and laser-based photoacoustic tomography (PAT) in a circular scanning configuration were both developed to image deeply seated lesions and objects in biological tissues. Because malignant breast tissue absorbs microwaves more strongly than benign breast tissue, cancers were imaged with good spatial resolution and contrast by TAT in human breast mastectomy specimens. Based on the intrinsic optical contrast between blood and chicken breast muscle, an embedded blood object that was 5 cm deep in the tissue was also detected using PAT at a wavelength of 1064 nm.