EPOXYAURAPTEN AND MARMIN FROM JUICE OIL IN HASSAKU (CITRUS-HASSAKU) AND THE SPASMOLYTIC ACTIVITY OF 7-GERANYLOXYCOUMARIN-RELATED COMPOUNDS
EPOXYAURAPTEN AND MARMIN FROM JUICE OIL IN HASSAKU (CITRUS-HASSAKU) AND THE SPASMOLYTIC ACTIVITY OF 7-GERANYLOXYCOUMARIN-RELATED COMPOUNDS
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DOI：
10.1080/00021369.1987.10868137
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发表时间：
1987-04-01
期刊：
影响因子：
--
通讯作者：
FUWA, H
中科院分区：
文献类型：
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作者：
YAMADA, Y;NAKATANI, N;FUWA, H
通过色谱法纯化从柑橘（Citrus hassaku）的汁液油中获得的沉淀物，得到7-香叶基氧基香豆素（aurapten）和两种化合物（mp 43.apprx. 45 ℃和122 ℃。124.degree. C），其结构被确定为doxxyaurapten和marmin的光谱证据的基础上。这些化合物均为首次从柑桔中分离得到。本文用离体雄性豚鼠小肠作实验，测定了由aurapten和marmin合成的aurapten、epoxyaurapten、marmin及其有关化合物的解痉活性。其中环氧金萝卜素对BaCl_2引起的小血管收缩的抑制作用最强。
Purification of the precipitates obtained from the juice oil of Citrus hassaku by chromatography afforded 7-geranyloxycoumarin (aurapten) and two compounds (mp 43 .apprx. 45.degree.C and 122 .apprx. 124.degree. C), whose structures were determined to be expoxyaurapten and marmin on the basis of spectral evidence. These compounds were isolated from Citrus hassaku for the first time. The spasmolytic activity was tested of aurapten, epoxyaurapten, marmin and their related compounds, which were synthesized from aurapten and marmin, on the small intestine removed from a male guinea pig. Epoxyaurapten exhibited the highest activity among them against the small intestine''s contraction induced by BaCl2.