HER3 over-expression and overall survival in gastrointestinal cancers.
HER3 over-expression and overall survival in gastrointestinal cancers.
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胃肠道癌症中 HER3 过度表达和总生存率
DOI：
10.18632/oncotarget.5998
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发表时间：
2015-12-15
期刊：
影响因子：
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通讯作者：
Duan G
中科院分区：
文献类型：
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作者：
Wang Y;Yang H;Duan G
已发表的关于胃肠道癌中人表皮因子受体3（HER 3）表达与总生存期（OS）之间相关性的研究产生了相互矛盾的结果。本研究的目的是探讨HER 3过表达与胃肠道肿瘤OS的关系。通过Medline/PubMed、Embase、Science Direct和Elsevier进行系统检索。计算总比值比（OR）和95%置信区间（CI），以估计相关性的强度。总体而言，我们观察到HER 3过表达与5年OS较差相关（OR = 1.38，95% CI：1.04-1.82）;然而，HER 3过表达与3年OS较差无关（OR = 1.33，95% CI：0.97-1.84）。累积荟萃分析显示了相似的结果。在按肿瘤类型进行的亚组分析中，胃癌中HER 3过表达与3年（OR = 1.69，95% CI：1.28-2.25）和5年（OR = 1.74，95% CI：1.26-2.41）时的OS较差相关。总之，我们的研究结果表明，HER 3过表达可能与胃癌的总生存率较差。需要设计良好的大样本研究来进一步证实我们的发现。
Published studies on the association between human epidermal factor receptor 3 (HER3) expression and overall survival (OS) in gastrointestinal cancers have yielded conflicting results. The aim of this study was to explore the association of HER3 over-expression with OS in gastrointestinal cancers. A systematic search was performed through Medline/PubMed, Embase, Science Direct and Elsevier. The summary odds ratio (OR) with 95% confidence interval (CI) was calculated to estimate the strength of the association. Overall, we observed that HER3 over-expression was associated with worse OS at five years (OR = 1.38, 95% CI: 1.04–1.82); however, HER3 over-expression was not associated with worse OS at three years (OR = 1.33, 95% CI: 0.97–1.84). The cumulative meta-analysis showed similar results. In subgroup analyses by tumor type, HER3 over-expression in gastric cancers was associated with worse OS at both three years (OR = 1.69, 95% CI: 1.28–2.25) and five years (OR = 1.74, 95% CI: 1.26–2.41). In conclusion, our results suggest that HER3 over-expression may be associated with worse overall survival in gastric cancers. Well-designed studies with a large sample size are required to further confirm our findings.