Apoptosis of Th1‐like cells in experimental tuberculosis (TB)
Apoptosis of Th1‐like cells in experimental tuberculosis (TB)
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实验性结核病 (TB) 中 Th1â 样细胞的凋亡
DOI：
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发表时间：
1999
影响因子：
4.6
通讯作者：
G. C. Mishra
中科院分区：
文献类型：
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作者：
Gobardhan Das;H. Vohra;Biswajit Saha;J. Agrewala;G. C. Mishra
在易感宿主体内进行性结核分枝杆菌感染期间，Th1 细胞诱导的抗分枝杆菌免疫力丧失。本研究旨在测试抗分枝杆菌细胞介导的免疫反应丧失的机制。我们证明结核分枝杆菌感染导致 CD4+ T 细胞中 Fas 表达增加和 Bcl-2 表达减少。当 CD4+ T 细胞在体外受到刺激时，它们显示细胞凋亡增加，IL-2 和干扰素 γ (IFN-γ) 的产生减少，但 IL-4 的产生却没有减少。这些变化可能导致 Th1 样细胞选择性凋亡，从而导致细胞介导的针对结核分枝杆菌的免疫反应丧失。
Th1 cell‐induced anti‐mycobacterial immunity is lost during a progressive Mycobacterium tuberculosis infection in a susceptible host. This study was designed to test the mechanism of the loss of anti‐mycobacterial cell‐mediated immune response. We demonstrate that M. tuberculosis infection results in increased Fas expression and decreased Bcl‐2 expression in CD4+ T cells. When CD4+ T cells are stimulated in vitro, they show increased apoptosis and decreased production of IL‐2 and interferon‐gamma (IFN‐γ) but not of IL‐4. These changes may result in selective apoptosis of Th1‐like cells, leading to the loss of cell‐mediated immune response against M. tuberculosis.