Differential selection of multidrug efflux systems by quinolones in Pseudomonas aeruginosa
Differential selection of multidrug efflux systems by quinolones in Pseudomonas aeruginosa
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DOI：
10.1128/aac.41.11.2540
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发表时间：
1997-11-01
影响因子：
4.9
通讯作者：
Pechere, JC
中科院分区：
文献类型：
--
作者：
Kohler, T;MicheaHamzehpour, M;Pechere, JC
对铜绿假单胞菌体外暴露于 12 种喹诺酮类药物后选择的耐药机制进行了分析。外排型突变体占主导地位。喹诺酮类药物选择特定流出系统的能力不同。虽然较新的氟喹诺酮类药物青睐 MexCD-OprJ 系统，但较旧的喹诺酮类药物仅选择 MexEF-OprN 或 MexAB-OprM 系统。可质子化的 C-7 取代基与 C-6 氟原子组合是参与外排泵底物特异性的喹诺酮类药物的结构决定因素。
Resistance mechanisms selected after in vitro exposure to 12 quinolones were analyzed for Pseudomonas aeruginosa. Efflux-type mutants were predominant. Quinolones differed in their ability to select a particular efflux system. While the newer fluoroquinolones favored the MexCD-OprJ system, the older quinolones selected exclusively the MexEF-OprN or MexAB-OprM systems. A protonable C-7 substituent in combination with a C-6 fluorine atom is a structural determinant of quinolones involved in efflux pump substrate specificity.