Neuronal Signaling by Thy-1 in Nanodomains With Specific Ganglioside Composition: Shall We Open the Door to a New Complexity?
Neuronal Signaling by Thy-1 in Nanodomains With Specific Ganglioside Composition: Shall We Open the Door to a New Complexity?
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DOI：
10.3389/fcell.2019.00027
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发表时间：
2019-03-07
影响因子：
5.5
通讯作者：
Herrera-Molina, Rodrigo
中科院分区：
文献类型：
--
作者：
Ilic, Katarina;Auer, Benedikt;Herrera-Molina, Rodrigo
Thy-1是一种小的膜糖蛋白，是细胞粘附分子免疫球蛋白超家族的成员。它在包括神经元在内的许多细胞类型中大量表达，并通过糖基磷脂酰肌醇尾锚定在外膜小叶上。Thy-1显示出许多有趣的特性，例如快速横向扩散，这使得它能够以不同的脂质组成进出膜纳米域。Thy-1在不同类型的细胞中广泛表达，并在细胞发育、粘附和分化中发挥作用。在这里，我们探讨了Thy-1在神经元信号传导中的功能，该功能由α-nu β（3）整联蛋白的细胞外结合启动，可能强烈依赖于细胞膜的脂质含量。此外，我们整理文献表明，协会的Thy-1与脂筏的特定成分，如唾液酸含有鞘糖脂，称为神经节苷脂。此外，我们认为，Thy-1的定位在nanodomains可能会受到神经节苷脂。基于神经元纳米结构域的潜在多样性，我们建议重新考虑和评估Thy-1在筏中定位的传统概念。
Thy-1 is a small membrane glycoprotein and member of the immunoglobulin superfamily of cell adhesion molecules. It is abundantly expressed in many cell types including neurons and is anchored to the outer membrane leaflet via a glycosyl phosphatidylinositol tail. Thy-1 displays a number of interesting properties such as fast lateral diffusion, which allows it to get in and out of membrane nanodomains with different lipid composition. Thy-1 displays a broad expression in different cell types and plays confirmed roles in cell development, adhesion and differentiation. Here, we explored the functions of Thy-1 in neuronal signaling, initiated by extracellular binding of alpha nu beta(3) integrin, may strongly dependent on the lipid content of the cell membrane. Also, we assort literature suggesting the association of Thy-1 with specific components of lipid rafts such as sialic acid containing glycosphingolipids, called gangliosides. Furthermore, we argue that Thy-1 positioning in nanodomains may be influenced by gangliosides. We propose that the traditional conception of Thy-1 localization in rafts should be reconsidered and evaluated in detail based on the potential diversity of neuronal nanodomains.