Anabolic and catabolic pathways regulating skeletal muscle mass.
Anabolic and catabolic pathways regulating skeletal muscle mass.
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DOI：
10.1097/mco.0b013e32833781b5
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发表时间：
2010-05
影响因子：
3.1
通讯作者：
Esser KA
中科院分区：
文献类型：
--
作者：
McCarthy JJ;Esser KA
本综述的目的是讨论最近的发现，因为它们涉及参与成人骨骼肌质量调节的合成代谢和分解代谢信号通路。过去几年进行的研究不断完善我们对控制骨骼肌质量途径的理解，特别是 mTOR、FoxO 和 NF-κB 途径。替代信号通路也已成为肌肉质量的重要调节因子，例如 β-连环蛋白通路。更好地了解调节骨骼肌质量的合成代谢和分解代谢过程对于开发更有效的治疗方法以防止因废用、衰老和疾病而导致的肌肉损失至关重要。
the purpose of this review is to discuss recent findings as they pertain to anabolic and catabolic signaling pathways involved in the regulation of adult skeletal muscle mass. research conducted over the past few years has continued to refine our understanding of the pathways that govern skeletal muscle mass, in particular the mTOR, FoxO and NF-κB pathways. Alternative signaling pathways have also emerged as important regulators of muscle mass such as the β-catenin pathway. a better understanding of the anabolic and catabolic processes which regulate skeletal muscle mass is critical for the development of more effective therapeutics to prevent the loss of muscle with disuse, aging and disease.