Ruthenium‐Catalyzed Enantioselective Propargylic Phosphinylation of Propargylic Alcohols with Phosphine Oxides
Ruthenium‐Catalyzed Enantioselective Propargylic Phosphinylation of Propargylic Alcohols with Phosphine Oxides
复制标题
钌催化的丙炔醇与氧化膦的对映选择性丙炔膦酰化反应
DOI：
10.1002/ange.202102779
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
and Yoshiaki Nishibayashi
中科院分区：
文献类型：
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作者：
Shiyao Liu;Yoshiaki Tanabe;Shogo Kuriyama;Ken Sakata;and Yoshiaki Nishibayashi
近年来，过渡金属催化的丙叉对映体选择性取代反应取得了很大进展，但目前还没有以磷为中心的亲核试剂成功应用的报道。在这里，我们报道了第一个成功的例子，作为磷中心的亲核剂，Ru催化的丙叉醇与二芳基膦氧化物的对映选择性丙叉取代反应。该合成方法为手性含磷有机化合物的制备提供了一种新的方法。
The development of transition metal‐catalyzed enantioselective propargylic substitution reactions has gained much progress in recent years, however, no successful example with phosphorus‐centered nucleophiles has yet been reported until now. Herein, we report the first successful example of ruthenium‐catalyzed enantioselective propargylic substitution reactions of propargylic alcohols with diarylphosphine oxides as phosphorus‐centered nucleophiles. This synthetic approach provides a new method to prepare chiral phosphorus‐containing organic compounds.