Epstein‐barr virus‐specific antibody‐dependent cellular cytotoxicity in patients with Burkitt's lymphoma
Epstein‐barr virus‐specific antibody‐dependent cellular cytotoxicity in patients with Burkitt's lymphoma
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伯基特淋巴瘤患者的 Epstein-barr 病毒特异性抗体依赖性细胞毒性
DOI：
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发表时间：
1979
影响因子：
6.4
通讯作者：
I. Bal
中科院分区：
文献类型：
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作者：
G. Pearson;L. Qualtiere;G. Klein;T. Norin;I. Bal
在抗体依赖性细胞毒性（ADCC）试验中，对来自54例非洲伯基特淋巴瘤（BL）患者的编码血清进行抗Epstein巴尔病毒（EBV）诱导的膜抗原抗体滴定。然后将滴度与化疗后淋巴瘤生长的进展相关。在74%具有高ADCC滴度（> 3，840）的患者中，淋巴瘤在治疗后显示部分或完全消退。在中等滴度组（240- 3，840）中，36%的淋巴瘤对治疗有一定反应，而低滴度组（<240）中只有29%的淋巴瘤对治疗有反应。这些初步结果表明，正如先前报道的鼻咽癌患者，ADCC滴度可能对这种EBV相关疾病患者具有预后价值。为了确定ADCC抗原的身份，检查了其中一些血清中迄今为止在EBV感染的Raji细胞膜中鉴定的四种主要MA组分的抗体。具有高ADCC滴度的血清通常含有针对四种主要MA组分的抗体，而低滴度血清通常含有针对这些蛋白质中的三种或更少的抗体。然而，这种模式也有例外，表明ADCC抗原可能与迄今为止鉴定的四种EBV诱导的膜组分不同。
Coded sera from 54 patients with African Burkitt's lymphoma (BL) were titrated for antibodies against an Epstein‐Barr virus (EBV)‐induced membrane antigen in the antibody‐dependent cellular cytotoxicity (ADCC) assay. The titers were then correlated with the progression of lymphoma growth following chemotherapy. In 74% of the patients with high ADCC titers (>3,840), lymphomas showed partial or complete regression following therapy. In the medium‐titered group (240–3,840), 36% of the lymphomas showed some response to therapy, while only 29% of the lymphomas in the low group (<240) responded to treatment. These preliminary results indicated that, as previously reported for patients with nasopharyngeal carcinoma, ADCC titers may be of prognostic value in patients with this EBV‐associated disease. In an attempt to determine the identity of the ADCC antigen, some of these sera were examined for antibody to the four major MA components so far identified in the membrane of EBV‐infected Raji cells. Sera with high ADCC titers in general contained antibody to the four major MA components, while low‐titered sera usually contained antibody to three or less of these proteins. There were exceptions to this pattern, however, indicating that the ADCC antigen might differ from the four EBV‐induced membrane components so far identified.