Cerebrovasodilation evoked by stimulation of subthalamic vasodilator area and hypoxia depends upon the integrity of cortical neurons in the rat.
Cerebrovasodilation evoked by stimulation of subthalamic vasodilator area and hypoxia depends upon the integrity of cortical neurons in the rat.
复制标题
刺激底丘脑血管舒张区域和缺氧引起的脑血管舒张取决于大鼠皮质神经元的完整性。
DOI：
10.1016/j.neulet.2004.06.063
复制
发表时间：
2004
影响因子：
2.5
通讯作者：
Golanov,EugeneV
中科院分区：
文献类型：
--
作者：
Ilch,ChristopherP;Golanov,EugeneV
In Sprague–Dawley rats symmetrical sites of the parietal cortex were microinjected with ibotenic acid (IBO, 10μg in 1μl) to lesion local neurons or with saline (1μl). Five days later, changes of cortical cerebral blood flow (CBF) in response to hypoxia and stimulation of the subthalamic vasodilator area (SVA) were measured using laser-Doppler flowmetry (LDF). The baseline CBF over the IBO- and saline-injected cortical sites did not differ significantly, but spontaneous waves of CBF were abolished over the lesioned sites. Elevations of CBF evoked by hypoxia or stimulation of SVA were attenuated by 54% and 88%, respectively (P < 0.05) over the lesioned sites, compared to saline-injected or non-injected sites. Hypercarbic cerebrovasodilation was comparable over all sites. We conclude that the SVA-evoked increase of CBF and about 50% of the hypoxia-evoked increase of CBF are mediated by excitation of cortical neurons.
