INCREASED SERUM IMMUNOGLOBULIN-E LEVELS FOLLOWING ALLOGENEIC BONE-MARROW TRANSPLANTATION
INCREASED SERUM IMMUNOGLOBULIN-E LEVELS FOLLOWING ALLOGENEIC BONE-MARROW TRANSPLANTATION
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DOI：
10.1016/0091-6749(80)90142-6
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发表时间：
1980-01-01
影响因子：
14.2
通讯作者：
ROSEN, FS
中科院分区：
文献类型：
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作者：
GEHA, RS;RAPPAPORT, JM;ROSEN, FS
对12例同种异体骨髓移植（BMT）术前及术后Ig[免疫球蛋白]E水平进行测定。再生障碍性贫血6例，白血病4例，Wiskott-Aldrich综合征和婴儿粒细胞缺乏症各1例。早在BMT后14天，12例患者中有10例的IgE水平急剧升高（7- 2000倍）。60天后，他们都恢复到基线水平。在这些患者中，6例患者伴有急性移植物抗宿主病（GVHD）的临床和生化证据。所有接受兔抗人胸腺细胞血清（ATS）用于移植准备的患者（n = 6）均采用放射变应原吸附试验（RAST）检测抗兔血清IgE抗体，RAST呈强阳性，且与总IgE水平一致。在急性GVHD期间检测到的这些高IgE水平可能是暂时缺乏抑制性T（胸腺源性）细胞活性的表现。
Ig[immunoglobulin]E levels were determined before and serially after allogeneic bone marrow transplantation (BMT) in 12 patients. Six patients had aplastic anemia, 4 leukemia, and 1 each Wiskott-Aldrich syndrome and infantile agranulocytosis. IgE levels increased sharply (7- to 2000-fold) in 10 of the 12 as early as 14 days after BMT. They all returned to baseline levels by 60 days. In 6 of these patients, the rise accompanied clinical and biochemical evidence of acute graft vs. host disease (GVHD). All of the patients who received rabbit antihuman thymocytic serum (ATS) in preparation for transplantation and were tested for IgE antirabbit serum antibody by radioallergosorbent test (RAST) (n = 6) developed a strongly positive RAST which paralleled their total IgE levels. These high IgE levels detected during the period of acute GVHD may be a manifestation of a transient lack of suppressor T [thymus-derived] cell activity.