Effect of Hydrophobic Interactions on Lower Critical Solution Temperature for Poly(N-isopropylacrylamide-co-dopamine Methacrylamide) Copolymers
Effect of Hydrophobic Interactions on Lower Critical Solution Temperature for Poly(N-isopropylacrylamide-co-dopamine Methacrylamide) Copolymers
复制标题
疏水相互作用对聚（N-异丙基丙烯酰胺-多巴胺甲基丙烯酰胺）共聚物较低临界溶解温度的影响
DOI：
10.3390/polym11060991
复制
发表时间：
2019-06-01
期刊：
影响因子：
5
通讯作者：
Stadler, Florian J.
中科院分区：
文献类型：
--
作者：
Garcia-Penas, Alberto;Biswas, Chandra Sekhar;Stadler, Florian J.
为了制备具有热响应性的共聚物，例如组织工程支架或药物载体，需要精确控制合成参数以设置较低的临界溶液温度(LCST)。然而，分子参数与LcST之间的关系是部分未知的，而且Lcst被定义为一个精确的温度，这过于简化了真实情况。用量热法、浊度法和流变学研究了N-异丙基丙烯酰胺(NIPAM)/多巴胺甲基丙烯酰胺(DMA)无规共聚物的相对分子质量和共聚物量的系统变化及其在水中的LCST。从观察到的转变中推导出结构信息，阐明了相对分子质量、共聚单体含量、端基效应或聚合度对LCST的贡献，并对其进行了统计建模。这证明可以通过溶液的分子结构和条件来预测LCST。而疏水的DMA降低了LCST，尤其是起始温度，聚合度对整个LCST范围的影响很大，但影响较小。
For the preparation of thermoresponsive copolymers, for e.g., tissue engineering scaffolds or drug carriers, a precise control of the synthesis parameters to set the lower critical solution temperature (LCST) is required. However, the correlations between molecular parameters and LCST are partially unknown and, furthermore, LCST is defined as an exact temperature, which oversimplifies the real situation. Here, random N-isopropylacrylamide (NIPAM)/dopamine methacrylamide (DMA) copolymers were prepared under a systematical variation of molecular weight and comonomer amount and their LCST in water studied by calorimetry, turbidimetry, and rheology. Structural information was deduced from observed transitions clarifying the contributions of molecular weight, comonomer content, end-group effect or polymerization degree on LCST, which were then statistically modeled. This proved that the LCST can be predicted through molecular structure and conditions of the solutions. While the hydrophobic DMA lowers the LCST especially the onset, polymerization degree has an important but smaller influence over all the whole LCST range.