VITAMIN-A AND FOLLICLE-STIMULATING-HORMONE SYNERGISTICALLY INDUCE DIFFERENTIATION OF TYPE-A SPERMATOGONIA IN ADULT-MOUSE CRYPTORCHID TESTES INVITRO
VITAMIN-A AND FOLLICLE-STIMULATING-HORMONE SYNERGISTICALLY INDUCE DIFFERENTIATION OF TYPE-A SPERMATOGONIA IN ADULT-MOUSE CRYPTORCHID TESTES INVITRO
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DOI：
10.1210/endo-114-3-801
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发表时间：
1984-01-01
期刊：
影响因子：
4.8
通讯作者：
NISHIMUNE, Y
中科院分区：
文献类型：
--
作者：
HANEJI, T;MAEKAWA, M;NISHIMUNE, Y
为研究维生素A和FSH对睾丸生殖细胞分化的作用机制，本实验采用体外培养的方法，对人工诱导的成年小鼠隐睾进行了研究。观察到维生素A化合物与FSH（但不与LH [促黄体生成素]）对睾丸生殖细胞分化的协同作用。FSH刺激A型精原细胞增殖，维甲酸诱导A型精原细胞向中间型或B型精原细胞分化。讨论了类维生素A和FSH对睾丸生殖细胞分化的可能作用机制。
To study the mechanism of vitamin A and FSH action on testicular germ cell differentiation, artificially induced cryptorchid testes of adult mice were cultured in vitro, because such testes contain only type A spermatogonia and Sertoli cells in their seminiferous tubules. A synergistic effect of vitamin A compounds with FSH, but not with LH [luteinizing hormone], on testicular germ cell differentiation was observed. Apparently FSH stimulated the proliferation of type A spermatogonia; retinoids induce spermatogenesis from type A spermatogonia into intermediate or type B spermatogonia. Possible mechanisms of action of retinoids and FSH on testicular germ cell differentiation are discussed.