Have we made progress in the management of chronic graft-vs-host disease?
Have we made progress in the management of chronic graft-vs-host disease?
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DOI：
10.1016/j.beha.2010.09.016
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发表时间：
2010-12
期刊：
影响因子：
--
通讯作者：
Lee SJ
中科院分区：
文献类型：
--
作者：
Lee SJ
慢性移植物抗宿主病（GVHD）是异基因造血细胞移植常见的长期并发症，与非常高的发病率和死亡率相关。为了了解我们在慢性GVHD的管理方面是否取得了进展，首先提出一个有意义的“进展”的定义是有帮助的。以下可以被认为是改善慢性GVHD管理的指标：慢性GVHD的发生率或严重程度降低，治疗的疗效更好或毒性降低，尽管存在慢性GVHD，但生活质量更好，以及总体和无病生存率提高。然而，迄今为止，这些领域尚未取得真实的进展，尽管出现了有希望的新的预防战略和治疗方法。此外，研究界已经就慢性GVHD的定义、管理和临床试验的进行等许多不同问题达成了共识。这些共识文件将有助于标准化工作和数据收集，以便将来可以进行真正的比较，并取得真实的临床进展。
Chronic graft-vs-host disease (GVHD) is a common long-term complication of allogeneic hematopoietic cell transplant that is associated with very high morbidity and mortality. In order to understand whether we have made progress in the management of chronic GVHD, it is helpful to first propose a definition of meaningful “progress.” The following can be considered to be indicators of improved management of chronic GVHD: a decrease in the incidence or severity of chronic GVHD, better efficacy or decreased toxicity of therapies, better quality of life despite chronic GVHD, and improved overall and disease-free survival rates. However, to date, real progress has not been made in these areas, though there are promising new preventive strategies and treatments. Furthermore, a consensus has been reached in the research community about many different issues surrounding chronic GVHD definitions, management, and the conduct of clinical trials. These consensus documents will help to standardize efforts and data collection so that true comparisons can be made in the future and real clinical progress achieved.
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