Delayed clearance of diazepam due to cimetidine.
Delayed clearance of diazepam due to cimetidine.
复制标题
西咪替丁导致地西泮的清除延迟。
DOI：
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复制
发表时间：
1980
影响因子：
158.5
通讯作者：
I. Reimann
中科院分区：
文献类型：
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作者：
U. Klotz;I. Reimann
西咪替丁可抑制微粒体代谢，从而损害口服抗凝剂和模型药物安替比林从血液中的消除。1，2地西泮和西咪替丁是最广泛使用的药物之一，许多患者同时接受这两种药物治疗。这两种药物之间的相互作用可能具有临床意义。我们已经写了一份初步报告，表明西咪替丁对地西泮处置的影响。3本文件介绍了相互作用的幅度和可能的机制的研究。我们研究了西咪替丁对地西泮和安替比林血浆水平的影响。方法交叉研究包括4个研究项目。
CIMETIDINE inhibits microsomal metabolism and hence impairs elimination of oral anticoagulants and the model drug antipyrine from the bloodstream.1 , 2 Diazepam and cimetidine are among the most widely used drugs, and many patients are treated with both at the same time. An interaction between these two drugs could be of clinical importance. We have written a preliminary report suggesting an effect of cimetidine on diazepam disposition.3 The present paper describes studies on the magnitude and possible mechanism of the interaction. We have investigated the effect of cimetidine on plasma levels of diazepam and antipyrine. Methods The crossover study consisted of four . . .