Form of the postsynaptic density. A serial section study.
Form of the postsynaptic density. A serial section study.
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DOI：
10.1083/jcb.78.1.36
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发表时间：
1978-07
期刊：
影响因子：
--
通讯作者：
Siekevitz P
中科院分区：
文献类型：
--
作者：
Cohen RS;Siekevitz P
通过对狗大脑皮层组织进行连续切片，可以在较大的突触后密度（PSD）中发现孔或穿孔，这证实了Peters和Kaisermann-Abramof（1969）的早期工作。Z.泽尔福施米克罗斯克Anat.100：487-506）。这些孔出现在连续切片中，这些连续切片恰好平行于和垂直于突触连接平面切割。在这个洞对面的突触间隙部分，没有裂缝物质。有时，与孔相对的突触前膜缩进突触前细胞。此外，大多数突触前细胞中的突触小泡靠近膜聚集在膜的那部分相对于密度盘的边缘。目前还不知道孔的含义和上述密度函数的其他特征。
Through the use of serial sectioning of dog cerebral cortex tissue, holes or perforations could be revealed in the larger postsynaptic densities (PSDs), in confirmation of the earlier work of Peters and Kaisermann-Abramof (1969. Z. Zellforsch. Mikrosk. Anat. 100:487-506). These holes appeared in serial sections which happened to be cut both parallel and normal to the plane of the synaptic junction. Cleft material was absent in that part of the synaptic cleft opposite this hole. Somestimes the presynaptic membrane opposite the hole was indented into the presynaptic cell. In addition, most of the synaptic vesicles in the presynaptic cell close to the membrane were clustered at that part of the membrane opposite the edge of the density disk. The meaning of the hole and of the other features mentioned above for the function of the density is not known at present.