Differences in clinical course between dementia with Lewy bodies and Alzheimer's disease
Differences in clinical course between dementia with Lewy bodies and Alzheimer's disease
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DOI：
10.1111/j.1468-1331.2008.02388.x
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发表时间：
2009-02-01
影响因子：
5.1
通讯作者：
Iwamoto, T.
中科院分区：
文献类型：
--
作者：
Hanyu, H.;Sato, T.;Iwamoto, T.
探讨路易体痴呆（DLB）与阿尔茨海默病（AD）在临床病程和认知进展变化方面是否存在差异。我们比较了56例DLB患者和111例AD患者从首次就诊到终点（因入院、死亡或住院而停止就诊）的时间。患者每12个月检查一次迷你精神状态检查（MMSE）得分，直至60个月。路易体痴呆患者到达终点的时间明显短于AD患者（中位时间：40个月vs 52个月，P < 0.0001）。DLB患者入院（或死亡）比例显著高于AD患者（30% vs. 14%, P < 0.05），而养老院安置差异无统计学意义（25% vs. 17%）。DLB组和AD组的纵向MMSE评分下降率相等。与阿尔茨海默氏症相比，路易体痴呆患者入院（或死亡）的风险更大，因为最常见的是与跌倒有关的损伤和支气管肺炎，但两组在认知能力下降的速度上没有差异。
To investigate whether there may be differences in the clinical course and changes in cognitive progression between dementia with Lewy bodies (DLB) and Alzheimer's disease (AD).We compared the time from the first visit to endpoints (discontinuation of visits because of admission, death, or institutionalization) between 56 patients with DLB and 111 patients with AD. Mini-Mental State Examination (MMSE) scores of patients were every 12 months examined up to 60 months.Dementia with Lewy bodies had a significantly shorter time to reaching endpoints than those with AD (median time; 40 months vs. 52 months, P < 0.0001). The proportion of admission (or death) was significantly higher in DLB than in AD (30% vs. 14%, P < 0.05), while the difference in institutionalization in nursing homes did not reach statistical significance (25% vs. 17%). Rates of longitudinal MMSE score decline for DLB and AD groups were equivalent.Dementia with Lewy bodies had a greater risk of admission (or death) because of most commonly fall-related injuries and bronchopneumonia than AD, but the two groups did not differ in rate of cognitive decline.