The role of prefrontal-subcortical circuitry in negative bias in anxiety: Translational, developmental and treatment perspectives.
The role of prefrontal-subcortical circuitry in negative bias in anxiety: Translational, developmental and treatment perspectives.
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DOI：
10.1177/2398212818774223
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发表时间：
2018-01
影响因子：
--
通讯作者：
Robinson OJ
中科院分区：
文献类型：
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作者：
Carlisi CO;Robinson OJ
焦虑症是发达国家精神疾病的最常见原因，但我们对症状和治疗的理解目前并不是基于对潜在神经生物学机制的了解。在这篇综述中，我们讨论了积累的工作，这些工作指出了前额叶-皮层下大脑回路在驱动焦虑症的核心心理症状——消极情感偏见中的作用。具体来说，我们指出人类和动物模型的融合工作，表明背侧和腹侧前额叶杏仁核回路分别在促进和抑制负偏差方面存在相互关系。我们讨论这些回路的发育轨迹如何导致青春期焦虑的发作，此外，有效的药物和心理治疗如何改变该回路内的活动平衡以改善负面偏见症状。总之，这些发现可能使我们更接近对焦虑症及其治疗的机制和神经生物学理解。
Anxiety disorders are the most common cause of mental ill health in the developed world, but our understanding of symptoms and treatments is not presently grounded in knowledge of the underlying neurobiological mechanisms. In this review, we discuss accumulating work that points to a role for prefrontal–subcortical brain circuitry in driving a core psychological symptom of anxiety disorders – negative affective bias. Specifically, we point to converging work across humans and animal models, suggesting a reciprocal relationship between dorsal and ventral prefrontal–amygdala circuits in promoting and inhibiting negative bias, respectively. We discuss how the developmental trajectory of these circuits may lead to the onset of anxiety during adolescence and, moreover, how effective pharmacological and psychological treatments may serve to shift the balance of activity within this circuitry to ameliorate negative bias symptoms. Together, these findings may bring us closer to a mechanistic, neurobiological understanding of anxiety disorders and their treatment.