Immunoglobulin free light chains as an inflammatory biomarker of heart failure with myocarditis
Immunoglobulin free light chains as an inflammatory biomarker of heart failure with myocarditis
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DOI：
10.1016/j.clim.2020.108455
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发表时间：
2020-08-01
影响因子：
8.6
通讯作者：
Mason, Jay W.
中科院分区：
文献类型：
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作者：
Matsumori, Akira;Shimada, Toshio;Mason, Jay W.
背景资料：在这项研究中，我们测量了免疫球蛋白游离轻链（FLC），这是心肌炎所致心力衰竭患者血清中的炎症生物标志物。方法：通过竞争性抑制多重Luminex（R）测定法，对来自美国心肌炎治疗试验的心力衰竭伴心肌炎患者的储存血清样本中的FLC κ和FLC λ进行了测定。结果：心力衰竭合并心肌炎患者血清中FLC κ/λ比值的中位浓度显著低于健康对照组，FLC κ/λ比值对心力衰竭合并心肌炎具有良好的诊断价值。此外，FLC κ/λ比是一个独立的预后因素，总生存率，并允许创建三个预后组结合N-末端前B型利钠肽。结论：这项研究表明，FLC κ/λ比是一个有前途的生物标志物心力衰竭心肌炎。
Background: In this study, we measured immunoglobulin free light chains (FLC), a biomarker of inflammation in the sera of patients with heart failure due to myocarditis.Methods: FLC kappa and FLC lambda were assayed in stored serum samples from patients with heart failure with myocarditis from the US myocarditis treatment trial by a competitive-inhibition multiplex Luminex(R) assay.Results: The median concentration of circulating FLC kappa/lambda ratio was significantly lower in the sera from patients with heart failure with myocarditis than in healthy controls, and FLC kappa/lambda ratio had good diagnostic ability for identification of heart failure with myocarditis. Further, FLC kappa/lambda ratio was an independent prognostic factor for overall survival, and allowed creation of three prognostic groups by combining with N-terminal pro-B-type natriuretic peptide.Conclusions: This study suggests that FLC kappa/lambda ratio is a promising biomarker of heart failure with myocarditis.