LUNG AS A FILTER FOR MICROBUBBLES
LUNG AS A FILTER FOR MICROBUBBLES
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DOI：
10.1152/jappl.1979.47.3.537
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发表时间：
1979-01-01
影响因子：
3.3
通讯作者：
HILLS, BA
中科院分区：
文献类型：
--
作者：
BUTLER, BD;HILLS, BA
在麻醉狗的股动脉上非侵入性地使用新的超声多普勒装置，以证明当将直径为14-189 μ m的微泡直接注入主动脉时，其可以检测到仔细校准的微泡。然后采用相同的评价技术检测当气体作为微泡或大剂量输注到静脉系统中时逸出到动脉系统中的任何气泡。来自18只狗的结果表明，在正常条件下，肺是极好的气泡过滤器，并且任何截止直径都小于22 μ m。当肺部严重气体过载（20 ml）或用肺血管扩张剂（氨茶碱）预处理时，气泡逃逸。犬制备和动脉多普勒装置似乎是未来研究的理想选择，以确定哪些其他因素可能会损害肺过滤微泡的能力。当检测到气泡逃逸到动脉系统时，与其保留在肺内时的效果相比，生理参数显示出显着变化。呼吸曲线的变化表明，它们可以提供静脉栓塞程度的有用指标，并警告即将发生的超负荷导致动脉栓塞。
A new ultrasonic Doppler device was used noninvasively over the femoral artery of anesthetized dogs to prove that it can detect carefully calibrated microbubbles of 14-189 .mu.m diameter when these are infused directly into the aorta. The same evaluated technique was then employed to detect any bubbles escaping into the arterial system when gas was infused into the venous system as microbubbles or as a bolus. Results from 18 dogs showed that, under normal conditions, the lungs are a superb filter for bubbles and that any cutoff diameter is less than 22 .mu.m. Bubbles escaped entrapment when the lungs were severely overloaded with gas (20 ml) or were pretreated with a pulmonary vasodilator (aminophylline). The dog preparation and arterial Doppler device appear to be ideal for future studies to determine what other factors might compromise the capability of the lungs to filter microbubbles. Physiological parameters showed dramatic changes when bubbles were detected as escaping into the arterial system by comparison with their effect when retained within the lungs. Changes in respiration profile indicated that they may offer a useful index of the degree of venous embolization and a warning of impending overload leading to arterial embolization.