Epigenetic Regulation in Uterine Fibroids-The Role of Ten-Eleven Translocation Enzymes and Their Potential Therapeutic Application.
Epigenetic Regulation in Uterine Fibroids-The Role of Ten-Eleven Translocation Enzymes and Their Potential Therapeutic Application.
复制标题
DOI：
10.3390/ijms23052720
复制
发表时间：
2022-02-28
影响因子：
5.6
通讯作者：
Al-Hendy A
中科院分区：
文献类型：
--
作者：
Włodarczyk M;Nowicka G;Ciebiera M;Ali M;Yang Q;Al-Hendy A
子宫肌瘤（UFs）是一种含有异常平滑肌细胞和细胞外基质（ECM）积累的单克隆良性肿瘤。虽然是良性的，但UFs是妇科和生殖功能障碍的主要来源，从月经过多和盆腔疼痛到不孕症、复发性流产和早产。许多危险因素通过遗传和表观遗传机制参与了UFs的发病机制。后者涉及DNA甲基化和去甲基化反应，提供特定的DNA甲基化模式，调节基因表达。由10 - 11易位蛋白（TETs）介导的活性DNA去甲基化反应和5-羟甲基胞嘧啶水平升高被认为参与UF的形成。本文就TET酶的功能及其活性失调可能引发UFs的研究进展作一综述。了解表观遗传学在UFs发病机制中的作用可能会导致一种新型的保生育药物治疗方法。
Uterine fibroids (UFs) are monoclonal, benign tumors that contain abnormal smooth muscle cells and the accumulation of extracellular matrix (ECM). Although benign, UFs are a major source of gynecologic and reproductive dysfunction, ranging from menorrhagia and pelvic pain to infertility, recurrent miscarriage, and preterm labor. Many risk factors are involved in the pathogenesis of UFs via genetic and epigenetic mechanisms. The latter involving DNA methylation and demethylation reactions provide specific DNA methylation patterns that regulate gene expression. Active DNA demethylation reactions mediated by ten-eleven translocation proteins (TETs) and elevated levels of 5-hydroxymethylcytosine have been suggested to be involved in UF formation. This review paper summarizes the main findings regarding the function of TET enzymes and their activity dysregulation that may trigger the development of UFs. Understanding the role that epigenetics plays in the pathogenesis of UFs may possibly lead to a new type of pharmacological fertility-sparing treatment method.
登录
查看更多内容
MicroRNA-29a通过TET-SOCS1-MMP9信号轴诱导5-羟甲基胞嘧啶丢失并促进肝细胞癌转移
影响因子：
9
作者：
Chen Q;Yin D;Zhang Y;Yu L;Li XD;Zhou ZJ;Zhou SL;Gao DM;Hu J;Jin C;Wang Z;Shi YH;Cao Y;Fan J;Dai Z;Zhou J
通讯作者：
Zhou J
影响因子：
64.5
作者：
Bhutani N;Burns DM;Blau HM
通讯作者：
Blau HM
影响因子：
6.5
作者：
Blum KA;Liu Z;Lucas DM;Chen P;Xie Z;Baiocchi R;Benson DM;Devine SM;Jones J;Andritsos L;Flynn J;Plass C;Marcucci G;Chan KK;Grever MR;Byrd JC
通讯作者：
Byrd JC
影响因子：
16.6
作者：
An J;González-Avalos E;Chawla A;Jeong M;López-Moyado IF;Li W;Goodell MA;Chavez L;Ko M;Rao A
通讯作者：
Rao A
影响因子：
8
作者：
Cao, Tiefeng;Jiang, Ying;Huang, Yingqun
通讯作者：
Huang, Yingqun