Tissue engineering: strategies, stem cells and scaffolds
Tissue engineering: strategies, stem cells and scaffolds
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DOI：
10.1111/j.1469-7580.2008.00878.x
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发表时间：
2008-07-01
影响因子：
2.4
通讯作者：
Roberts, Scott J.
中科院分区：
文献类型：
--
作者：
Howard, Daniel;Buttery, Lee D.;Roberts, Scott J.
组织工程支架旨在影响细胞群周围的物理、化学和生物环境。在这篇综述中，我们重点介绍我们自己的工作，介绍一系列用于组织工程的策略和材料，包括适合组织工程的细胞来源：胚胎干细胞、骨髓源性间充质干细胞和脐带源性间充质干细胞。此外，我们强调定制支架设计和制造的发展，重点介绍激光烧结、超临界二氧化碳加工、生长因子掺入和分区、支架表面的等离子体改性以及新型多用途温度敏感可注射材料。
Tissue engineering scaffolds are designed to influence the physical, chemical and biological environment surrounding a cell population. In this review we focus on our own work and introduce a range of strategies and materials used for tissue engineering, including the sources of cells suitable for tissue engineering: embryonic stem cells, bone marrow-derived mesenchymal stem cells and cord-derived mesenchymal stem cells. Furthermore, we emphasize the developments in custom scaffold design and manufacture, highlighting laser sintering, supercritical carbon dioxide processing, growth factor incorporation and zoning, plasma modification of scaffold surfaces, and novel multi-use temperature-sensitive injectable materials.