Sphingolipids as biomarkers of fumonisin exposure and risk of esophageal squamous cell carcinoma in China
Sphingolipids as biomarkers of fumonisin exposure and risk of esophageal squamous cell carcinoma in China
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DOI：
10.1023/a:1012228000014
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发表时间：
2001-11-01
影响因子：
2.3
通讯作者：
Dawsey, SM
中科院分区：
文献类型：
--
作者：
Abnet, CC;Borkowf, CB;Dawsey, SM
目的：食管鳞状细胞癌（ESCC）的病理学研究报告与食用被轮枝镰刀菌污染的玉米有关，轮枝镰刀菌产生被称为伏马菌素的真菌毒素。伏马菌素破坏鞘脂代谢，血清鞘脂已被提议作为伏马菌素暴露的生物标志物。我们进行了一项前瞻性巢式病例对照研究，以探讨血清鞘脂和ESCC发病率之间的关系。方法：病例和对照组选自一个大型的前瞻性试验在林县，中华人民共和国。从最初5.25年随访期间确定的639例ESCC事件中随机选择了98例ESCC病例;根据6个年龄和性别分层的病例分布，还随机选择了185例对照。通过高效液相色谱法测定研究基线时收集的血清中二氢鞘氨醇和鞘氨醇的浓度。结果：在校正年龄、性别、吸烟和饮酒的条件和非条件Logistic回归模型中，未发现血清鞘氨醇、二氢鞘氨醇或二氢鞘氨醇/鞘氨醇比值与ESCC发病率之间存在显著相关性。我们的研究是第一个前瞻性研究，以评估鞘脂水平之间的关系，作为伏马菌素暴露的生物标志物，和癌症发病率。我们发现鞘脂水平与ESCC风险之间没有显著相关性。
Objective: Ecologic studies of esophageal squamous cell carcinoma (ESCC) have reported an association with consumption of maize contaminated with Fusarium verticillioides, which produce fungal toxins referred to as fumonisins. Fumonisins disrupt sphingolipid metabolism and serum sphingolipids have been proposed as biomarkers of fumonisin exposure. We conducted a prospective nested case-control study to examine the relationship between serum sphingolipids and ESCC incidence.Methods: Cases and controls were selected from a large prospective trial conducted in Linxian, People's Republic of China. Ninety-eight ESCC cases were randomly selected from the 639 incident ESCC ascertained during the initial 5.25 years of follow-up; 185 controls were also randomly selected based on the distribution of cases among six age and sex strata. Concentrations of sphinganine and sphingosine were determined by high-performance liquid chromatography in serum collected at the study baseline.Results: No significant associations were found between serum sphingosine, sphinganine, or the sphinganine/sphingosine ratio and ESCC incidence in conditional and unconditional logistic regression models with adjustment for age, sex, tobacco use, and alcohol use.Conclusion: Our study is the first prospective study to assess the relationship between sphingolipid levels, as biomarkers of fumonisin exposure, and cancer incidence. We found no significant association between sphingolipid levels and risk of ESCC.