X-linked locus associated with hypertensive renal disease susceptibility in Dahl rats.
X-linked locus associated with hypertensive renal disease susceptibility in Dahl rats.
复制标题
X 连锁基因座与 Dahl 大鼠高血压肾病易感性相关。
DOI：
10.1097/00004872-200301000-00015
复制
发表时间：
2003
影响因子：
4.9
通讯作者：
Ruiz-Opazo,Nelson
中科院分区：
文献类型：
--
作者：
Herrera,VictoriaLM;Traverse,Sarah;Lopez,LyleV;Ruiz-Opazo,Nelson
Objective There is increasing evidence that genetic factors contribute to renal disease susceptibility associated with essential hypertension. To what extent these genetic factors act independently of hypertension susceptibility remains undetermined. The present study was undertaken to assess the potential chromosome X influence on target organ renal disease in the Dahl rat model of salt-sensitive hypertension.Subjects and methods Dahl S, Dahl R, F1 (RXS), F1 (SXR) and F2 (RXS) rat male populations were phenotyped for hypertensive renal disease by measuring the percent of incidence of the Grade IV Raij renal pathology score. Six chromosome X markers informative for our (RXS) intercross were analyzed in our F2 rat population (n= 105) for co-segregation with hypertensive renal disease and blood pressure characterized by radiotelemetry.Results Comparison of the incidence of renal disease (histologically determined) between F1 reciprocal intercross male progenies reveals a significant chromosome X effect on renal disease [percent incidence of Grade IV Raij renal pathology score in F1 (R female× S male) male rats= 2.75±0.66, and in F1 (S female× R male) male rats= 0.67±0.42; P= 0.02]. QTL analysis on an F2 (RXS) male population phenotyped for renal disease susceptibility (percent incidence of Grade IV Raij renal pathology score) detects significant linkage to DXRat98 (likelihood ratio statistic= 9.4, P= 0.00223) on chromosome X, corroborating X-linkage of renal disease susceptibility in Dahl rats.Conclusions Our results demonstrate the existence of an X-linked locus associated with hypertensive renal disease susceptibility in Dahl rats. Furthermore, the chromosome X markers tested did not co-segregate with hypertension, indicating that the gene (s) on chromosome X influence renal disease susceptibility independent of blood pressure.
