Laminins
Laminins
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DOI：
10.1007/s00441-009-0838-2
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发表时间：
2010-01-01
影响因子：
3.6
通讯作者：
Durbeej, Madeleine
中科院分区：
文献类型：
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作者：
Durbeej, Madeleine
层粘连蛋白是细胞粘附分子，其包含主要在基底膜中发现的糖蛋白家族，基底膜是位于上皮细胞和内皮细胞之下并围绕肌肉细胞、许旺细胞和脂肪细胞的细胞外基质的薄片。许多层粘连蛋白通过与细胞表面受体的相互作用自组装形成与细胞保持紧密结合的网络。层粘连蛋白对许多生理功能至关重要。它们对于早期胚胎发育和器官发生是必不可少的，并且在包括肌肉、神经、皮肤、肾、肺和脉管系统的若干组织中具有关键功能。关于层粘连蛋白的大量数据是可用的，并且在此不尝试进行深入描述。在这篇综述中，我将提供层粘连蛋白的结构，组织分布和与其他基质分子和受体的相互作用的快照，并简要描述层粘连蛋白在小鼠和人类的突变。一些启发性和及时的评论引用，可以参考原始文章和更详细的信息层粘连蛋白。
Laminins are cell adhesion molecules that comprise a family of glycoproteins found predominantly in basement membranes, which are the thin sheets of extracellular matrix that underlie epithelial and endothelial cells and surround muscle cells, Schwann cells, and fat cells. Many laminins self-assemble to form networks that remain in close association with cells through interactions with cell surface receptors. Laminins are vital for many physiological functions. They are essential for early embryonic development and organogenesis and have crucial functions in several tissues including muscle, nerve, skin, kidney, lung, and the vasculature. A great wealth of data on laminins is available, and an in-depth description is not attempted here. In this review, I will instead provide a snapshot of laminin structure, tissue distribution, and interactions with other matrix molecules and receptors and briefly describe laminin mutations in mice and humans. Several illuminating and timely reviews are cited that can be consulted for references to original articles and more detailed information concerning laminins.