Abnormal changes in functional connectivity between the amygdala and frontal regions are associated with depression in Alzheimer's disease
Abnormal changes in functional connectivity between the amygdala and frontal regions are associated with depression in Alzheimer's disease
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DOI：
10.1007/s00234-018-2100-7
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发表时间：
2018-12-01
期刊：
影响因子：
2.8
通讯作者：
Chen, Wei
中科院分区：
文献类型：
--
作者：
Guo, Zhongwei;Liu, Xiaozheng;Chen, Wei
目的应用静息态功能磁共振成像（rs-fMRI）技术研究阿尔茨海默病伴抑郁症（D-AD）患者杏仁核的功能连接（FC）。采用汉密尔顿抑郁量表和神经精神量表评定抑郁程度。杏仁核被用作FC分析的种子。结果与nD-AD患者相比，D-AD患者杏仁核、眶额皮质FC值增高，杏仁核、内侧前额叶皮质FC值降低，结论杏仁核-前额叶FC异常可能是AD伴发抑郁症的一个重要特征。
PurposeThe aim of the present study was to investigate the functional connectivity (FC) of Alzheimer's disease patients with depression (D-AD) based on an amygdalar seed using resting-state functional magnetic resonance imaging (rs-fMRI).MethodsTwenty-one non-depressed AD (nD-AD) patients and 21 D-AD patients underwent rs-fMRI. The Hamilton Depression Rating Scale and Neuropsychiatric Inventory were used to evaluate the severity of depression. The amygdala was used as the seed for FC analysis. The FC differences between the two groups were evaluated by two-sample t tests, and the correlation of FC changes with depressive severity was analyzed by Pearson correlational analysis.ResultsCompared with the nD-AD patients, D-AD patients had increased FC values between the amygdala and orbitofrontal cortex and decreased FC values among the amygdala, medial prefrontal cortex, and inferior frontal gyrus.ConclusionThese data suggest that abnormal amygdala-prefrontal FC may be an important characteristic of AD patients with depression.