Incorporation and distribution of strontium in bone
Incorporation and distribution of strontium in bone
复制标题
DOI：
10.1016/s8756-3282(01)00419-7
复制
发表时间：
2001-04-01
期刊：
影响因子：
4.1
通讯作者：
Christiansen, C
中科院分区：
文献类型：
--
作者：
Dahl, SG;Allain, P;Christiansen, C
在大鼠、猴子和人类口服锶（氯化锶或雷奈酸锶）后，对锶在骨中的分布和掺入进行了研究。在重复给药足够长的时间（在大鼠中至少4周）后，锶掺入骨中达到平台水平。由于吸收过程的差异，雌性中的该平台似乎低于雄性中的平台。与骨骼中相比，大鼠体内的锶血浆浓度达到稳态的速度更快，并且在 10 天内达到稳态。骨骼中的锶含量根据解剖部位的不同而变化。然而，不同骨骼部位的锶水平密切相关，腰椎的锶含量可以通过猴子的髂嵴骨活检来估计。骨骼中的锶含量也根据骨骼结构而变化，松质骨中的锶含量高于皮质骨。此外，在晶体水平上，在新形成的骨骼中观察到的锶浓度高于旧骨骼中的锶浓度。停止治疗后，猴子骨中锶含量迅速下降。锶从骨中的清除率相对较高可以通过其掺入机制来解释。锶主要通过交换结合到晶体表面，在新骨中，只有少数锶原子可以通过钙的离子取代结合到晶体中。停止治疗后，交换到晶体上的锶迅速消除，导致骨总锶水平迅速下降。总之，锶并入骨中（主要通过交换到晶体表面）取决于治疗持续时间、剂量、性别和骨骼部位。然而，骨中的锶含量与血浆中的锶水平高度相关，并且在骨中，不同骨骼部位之间的锶含量也高度相关。 (Bone 28: 446-453; 2001) (C) 2001 Elsevier Science Inc. 保留所有权利。
The distribution and incorporation of strontium into bone has been examined in rats, monkeys, and humans after oral administration of strontium (either strontium chloride or strontium ranelate), After repeated administration for a sufficient period of time (at least 4 weeks in rats), strontium incorporation into bone reaches a plateau level, This plateau appears to be lower in females than in males due to a difference in the absorption process. Steady-state plasma strontium levels are reached more rapidly than in bones, and within 10 days in the rat. The strontium levels in bone vary according to the anatomical site. However, strontium Levels at different skeletal sites are strongly correlated, and the strontium content of the lumbar vertebra may be estimated from iliac crest bone biopsies in monkeys. The strontium levels in bone also vary according to the bone structure and higher amounts of strontium are found in cancellous bone than in cortical bone. Furthermore, at the crystal level, higher concentrations of strontium are observed in newly formed bone than in old bone. After withdrawal of treatment, the bone strontium content rapidly decreases in monkeys. The relatively high clearance rate of strontium from bone can be explained by the mechanisms of its incorporation. Strontium is mainly incorporated by exchange onto the crystal surface, In new bone, only a few strontium atoms may be incorporated into the crystal by ionic substitution of calcium. After treatment withdrawal, strontium exchanged onto the crystal is rapidly eliminated, which leads to a rapid decrease in total bone strontium levels, In summary, incorporation of strontium into bone, mainly by exchange onto the crystal surface, is dependent on the duration of treatment, dose, gender, and skeletal site. Nevertheless, bone strontium content is highly correlated with plasma strontium levels and, in bone, between the different skeletal sites. (Bone 28: 446-453; 2001) (C) 2001 by Elsevier Science Inc. All rights reserved.