Antitumor agents, 118. The isolation and characterization of bruceanic acid A, its methyl ester, and the new bruceanic acids B, C, and D, from Brucea antidysenterica.
Antitumor agents, 118. The isolation and characterization of bruceanic acid A, its methyl ester, and the new bruceanic acids B, C, and D, from Brucea antidysenterica.
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抗肿瘤剂，118。来自抗痢疾鸦胆子的鸦胆子酸 A、其甲酯以及新的鸦胆子酸 B、C 和 D 的分离和表征。
DOI：
10.1021/np50072a020
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发表时间：
1990
影响因子：
5.1
通讯作者：
Lee,KH
中科院分区：
文献类型：
--
作者：
Toyota,T;Fukamiya,N;Okano,M;Tagahara,K;Chang,JJ;Lee,KH
已知的鸦胆子酸A [1]及其甲酯2，以及新的鸦胆子酸B [3]、C {4]和D [5]，已从鸦胆子中分离出来。化合物1-5的结构经波谱分析鉴定。化合物1表现出对KB和TE 671肿瘤细胞的细胞毒性。化合物5对P-388淋巴细胞白血病细胞具有细胞毒活性，本文报道了六个新的抗白血病苦木素类化合物：鸦胆子甙A、B（1）和C（2），鸦胆子醇A、B（3）和C（4），三个已知化合物：苦木甙G、N（2）和M（5）;和抗白血病细胞毒生物碱（6，7）。（Simaroubaceae）。我们现在描述新化合物的分离和表征，即鸦胆子酸B [31]、C [4]和D [5]，以及沿着从同一种植物中分离的已知化合物1和2。化合物1，命名为bruceanic acid A，先前由Kupchan埃塔尔从该植物中分离得到。（八）、化合物2，由Kupchan埃塔尔用CH 2N 2甲基化1制备。(8)首次从B的CHC_（13）提取物中分离得到一个新的化合物。安提特里亚我们。化合物1显示出对KB和TE 671肿瘤细胞的细胞毒性。化合物5对P-388白血病细胞具有细胞毒性。
The knownbruceanic acid A [1] and its methyl ester 2, as well as the new bruceanic acids B [3], C {4], and D [5], have been isolated from Brucea antidysenterica. The structures of 1-5 were elucidated by spectral data. Compound 1 demonstrated cytotoxicity against KB and TE671 tumor cells. Compound 5 was cytotoxic against P-388 lymphocytic leukemia cells.We reported previously the isolation and structural elucidation of six new an-tileukemic quassinoids, bruceantinosides A, B (1), and C (2) and bruceanols A, B (3), and C (4); three known compoundsyadanziosides G, N (2), and M (5); and cytotoxic antileukemic alkaloids (6, 7) from the stem of Brucea antidysenterica Mill.(Simaroubaceae). We now describe the isolation and characterization of the new com-pounds, bruceanic acids B [31, C [4], and D [5], along with the known compounds 1 and 2 from this same plant. Compound 1, which is named as bruceanic acid A, was isolated previously from this same plant by Kupchan etal.(8). Compound 2, prepared by methylation of 1 with CH2N2 by Kupchan etal.(8), was isolated for the first time from the CHC13 extract of B. antidysenterica by us. Compound 1 showed cytotoxicity against KB and TE671 tumor cells. Compound 5 was cytotoxic against P-388 leukemia cells.