Tissue engineering for bone defect heating: An update on a multi-component approach
Tissue engineering for bone defect heating: An update on a multi-component approach
复制标题
DOI：
10.1016/s0020-1383(08)70011-1
复制
发表时间：
2008-09-01
影响因子：
2.5
通讯作者：
Schieker, Matthias
中科院分区：
文献类型：
--
作者：
Drosse, Inga;Volkmer, Elias;Schieker, Matthias
多年来，科学界已经认识到为建立治疗骨缺损的新治疗策略需要采用跨学科方法。当看到众多方法时——从基于细胞的策略到基于支架的策略，还包括使用成骨生长因子以及基因工程，目前正在将这些方法结合起来评估它们开发治疗骨组织大量缺失的有效方案的潜力，这种认识就更加明显。本综述着重关注该领域的临床前研究，目的是对目前在骨组织工程中正在研究的多组分方法进行更新。（C）2008爱思唯尔有限公司。保留所有权利。
The need for an interdisciplinary approach in order to establish new therapeutic strategies for the therapy of bone defects has been acknowledged by the scientific community for many years. This awareness makes itself felt when looking at the multitude of approaches - ranging from cell-based to scaffold-based strategies and also including the use of osteogenic growth factors and genetic engineering that are currently being combined to assess their potential to develop effective concepts for the treatment of extensive loss of osseous tissue. With a strong focus on the preclinical research in this field, the goal of this review is to give an update on the multi-component approaches that are currently being investigated in tissue engineering of bone. (C) 2008 Elsevier Ltd. All rights reserved.