Resveratrol-induced apoptosis is enhanced by inhibition of autophagy in esophageal squamous cell carcinoma
Resveratrol-induced apoptosis is enhanced by inhibition of autophagy in esophageal squamous cell carcinoma
复制标题
通过抑制食管鳞状细胞癌的自噬增强白藜芦醇诱导的细胞凋亡
DOI：
10.1016/j.canlet.2013.03.023
复制
发表时间：
2013-08-19
期刊：
影响因子：
9.7
通讯作者：
Zhang, Hao
中科院分区：
文献类型：
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作者：
Tang, Qishan;Li, Guanwu;Zhang, Hao
研究了白藜芦醇对人食管鳞状细胞癌（ESCC）的抗癌作用，重点研究了其自噬作用及其对凋亡细胞死亡的影响。我们证明了白藜芦醇通过诱导细胞周期阻滞在亚g1期并导致随后的凋亡，以剂量依赖的方式抑制ESCC细胞的生长。在机制上，白藜芦醇诱导的ESCC细胞自噬与AMPK/mTOR通路无关。由于自噬的药理学和遗传学抑制增强了白藜芦醇诱导的ESCC细胞毒性，这为增强白藜芦醇和其他化疗试剂在ESCC癌症治疗中的抗癌作用提供了一种新的策略。2013爱思唯尔爱尔兰有限公司版权所有。
The anti-cancer activity of resveratrol in human esophageal squamous cell carcinoma (ESCC) was investigated focusing on the role of autophagy and its effects on apoptotic cell death. We demonstrated that resveratrol inhibits ESCC cell growth in a dose-dependent manner by inducing cell cycle arrest at the sub-G1 phase and resulting in subsequent apoptosis. Mechanistically, resveratrol-induced autophagy in the ESCC cells is AMPK/mTOR pathway independent. Since both pharmacological and genetic inhibition of autophagy enhanced the resveratrol-induced cytotoxicity to the ESCC cells, this provided a novel strategy in potentiating the anti-cancer effects of resveratrol and other chemotherapeutic reagents in ESCC cancer treatment. (C) 2013 Elsevier Ireland Ltd. All rights reserved.