Magnetoactive sponges for dynamic control of microfluidic flow patterns in microphysiological systems
Magnetoactive sponges for dynamic control of microfluidic flow patterns in microphysiological systems
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DOI：
10.1039/c3lc51076j
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发表时间：
2014-01-01
期刊：
影响因子：
6.1
通讯作者：
Zhao, Xuanhe
中科院分区：
文献类型：
--
作者：
Hong, Sungmin;Jung, Youngmee;Zhao, Xuanhe
我们开发了一种微流体流量控制系统，能够根据需要动态生成各种流动模式。该流量控制系统基于嵌入微流体通道中的新型磁活性海绵。施加不均匀磁场会压缩磁活性海绵，显着降低孔隙率和导水率。调节所施加的磁场可以动态地改变微流体通道中的流速。已经实现了频率在 1 到 3 Hz 之间、流速在 0.5 到 10 μL min(-1) 之间、持续时间超过 3 周的脉动和生理流动模式。工程化血管中的平滑肌细胞在脉动而非稳定流动下灌注了 7 天，与流动方向垂直排列，类似于体内方向。由于其相对于传统流量控制方法的各种优势，该新系统在基于微流体的微生理系统中具有潜在的重要应用，以模拟血流的生理性质。
We developed a microfluidic flow-control system capable of dynamically generating various flow patterns on demand. The flow-control system is based on novel magnetoactive sponges embedded in microfluidic flow channels. Applying a non-uniform magnetic field compresses the magnetoactive sponge, significantly reducing porosity and hydraulic conductivity. Tuning the applied magnetic field can dynamically vary the flow rate in the microfluidic channel. Pulsatile and physiological flow patterns with frequency between 1 and 3 Hz, flow rates between 0.5 and 10 mu L min(-1) and duration over 3 weeks have been achieved. Smooth muscle cells in engineered blood vessels perfused for 7 days aligned perpendicular to the flow direction under pulsatile but not steady flow, similar to the in vivo orientation. Owing to its various advantages over traditional flow-control methods, the new system potentially has important applications in microfluidic-based microphysiological systems to simulate the physiological nature of blood flow.