Common spontaneous sex-reversed XX males of the medaka Oryzias latipes.
Common spontaneous sex-reversed XX males of the medaka Oryzias latipes.
复制标题
青鳉中常见的自发性别逆转 XX 雄性。
作者：
I. Nanda;U. Hornung;M. Kondo;M. Schmid;M. Schartl
在medaka中，dmrt1基因的复制版本dmrt1bY已被确定为Y染色体上主要男性性别决定基因的候选基因。通过筛选北方和南方medaka的几个品系，我们发现相当多的雄性表型正常，生育能力不受影响，但缺乏dmrt1bY。这类雄虫的出现频率在某些品系中为10%，在其他品系中为零。通过FISH分析、PCR和表型分析分析其他y连锁标记的存在，表明其基因型为XX。这样的雄性与XX只雌性杂交会导致后代出现强烈的雌性偏见，并且在接下来的几代中也会出现XX只雄性。这表明，候选男性性别决定基因dmrt1bY可能并非在所有情况下都是男性发育所必需的，但其功能可以被迄今尚未确定的常染色体修饰基因所取代。
In the medaka, a duplicated version of the dmrt1 gene, dmrt1bY, has been identified as a candidate for the master male sex-determining gene on the Y chromosome. By screening several strains of Northern and Southern medaka we identified a considerable number of males with normal phenotype and uncompromised fertility, but lacking dmrt1bY. The frequency of such males was >10% in some strains and zero in others. Analysis for the presence of other Y-linked markers by FISH analysis, PCR, and phenotype indicated that their genotype is XX. Crossing such males with XX females led to a strong female bias in the offspring and also to a reappearance of XX males in the following generations. This indicated that the candidate male sex-determining gene dmrt1bY may not be necessary for male development in every case, but that its function can be taken over by so far unidentified autosomal modifiers.
影响因子：
10.5
作者：
Raymond, CS;Murphy, MW;Zarkower, D
通讯作者：
Zarkower, D
影响因子：
3.3
作者：
D. Morizot;S. Slaugenhaupt;Klaus D. Kallman;Aravinda Chakravartit
通讯作者：
D. Morizot;S. Slaugenhaupt;Klaus D. Kallman;Aravinda Chakravartit