Interplay of Inhibition and Excitation Shapes a Premotor Neural Sequence
Interplay of Inhibition and Excitation Shapes a Premotor Neural Sequence
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DOI：
10.1523/jneurosci.4346-14.2015
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发表时间：
2015-01-21
影响因子：
5.3
通讯作者：
Long, Michael A.
中科院分区：
文献类型：
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作者：
Kosche, Georg;Vallentin, Daniela;Long, Michael A.
在斑马雀中，歌唱行为是由位于前脑HVC核(专有名称)的运动前神经元内的一系列爆发驱动的。除了这些兴奋性投射神经元，HVC还含有抑制性中间神经元，其在运动前模式中的作用尚不清楚。在这里，我们使用了一系列电生理和行为观察来测试前面描述的模型，这些模型表明抑制性中间神经元在歌曲产生中扮演着不同的功能角色。我们证明，单个HVC运动前神经元爆发足以驱动神经元间网络中的结构性活动，因为它普遍存在并促进突触连接。我们描述了歌唱过程中神经元间的活动，并描述了这些神经元放电的可靠停顿。然后，我们证明了这些抑制间隙可能是驱动HVC前运动神经元正常爆发行为所必需的，并暗示结构性抑制和兴奋可能是在其他电路中产生序列的一般机制。
In the zebra finch, singing behavior is driven by a sequence of bursts within premotor neurons located in the forebrain nucleus HVC (proper name). In addition to these excitatory projection neurons, HVC also contains inhibitory interneurons with a role in premotor patterning that is unclear. Here, we used a range of electrophysiological and behavioral observations to test previously described models suggesting discrete functional roles for inhibitory interneurons in song production. We show that single HVC premotor neuron bursts are sufficient to drive structured activity within the interneuron network because of pervasive and facilitating synaptic connections. We characterize interneuron activity during singing and describe reliable pauses in the firing of those neurons. We then demonstrate that these gaps in inhibition are likely to be necessary for driving normal bursting behavior in HVC premotor neurons and suggest that structured inhibition and excitation may be a general mechanism enabling sequence generation in other circuits.