Atrial Fibrillation Current Knowledge and Future Directions in Epidemiology and Genomics
Atrial Fibrillation Current Knowledge and Future Directions in Epidemiology and Genomics
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DOI：
10.1161/circulationaha.111.039677
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发表时间：
2011-11-01
期刊：
影响因子：
37.8
通讯作者：
Benjamin, Emelia J.
中科院分区：
文献类型：
--
作者：
Magnani, Jared W.;Rienstra, Michiel;Benjamin, Emelia J.
心房颤动 (AF) 具有重要的公共卫生意义，会大大增加发病率、死亡率和健康相关支出。发病率包括心力衰竭和中风等心血管结局风险增加，以及对生活质量 (QOL)、功能状态和认知的有害影响。房颤的临床流行病学、其危险因素及其结果已得到广泛研究。过去十年的遗传学进展促进了与 AF 相关的突变和常见多态性的识别。代谢组学、蛋白质组学和其他“组学”技术最近才应用于房颤的研究，尚未得到系统研究。系统生物学方法虽然仍处于起步阶段，但有望为影响房颤风险的途径提供新的见解。在本综述中，我们讨论了房颤流行病学和基因组学的现状。我们试图强调流行病学和组学进展将如何促进系统生物学方法的发展，该方法将有助于阐明 AF 治疗的发病机制、风险分层和新靶标。我们的目的是阐明依赖于将 AF 流行病学和基因组学的新科学进展整合起来的问题和挑战。作为参考，我们在仅限在线的数据补充中提供了术语表。
Atrial fibrillation (AF) is of public health importance and profoundly increases morbidity, mortality, and healthrelated expenditures. Morbidities include the increased risks of cardiovascular outcomes such as heart failure and stroke and the deleterious effects on quality of life (QOL), functional status, and cognition. The clinical epidemiology of AF, its risk factors, and its outcomes have been investigated extensively. Genetic advances over the last decade have facilitated the identification of mutations and common polymorphisms associated with AF. Metabolomics, proteomics, and other “omics” technologies have only recently been applied to the study of AF, and have not yet been systematically investigated. Systems biology approaches, although still in their infancy, offer the promise of providing novel insights into pathways influencing AF risk. In the present review, we address the current state of the epidemiology and genomics of AF. We seek to emphasize how epidemiology and omic advances will contribute to a systems biology approach that will help to unravel the pathogenesis, risk stratification, and novel targets for AF therapies. Our purpose is to articulate questions and challenges that hinge on integrating novel scientific advances in the epidemiology and genomics of AF. As a reference, we have provided a glossary in the online-only Data Supplement.