Zebrafish frizzled-2 morphant displays defects in body axis elongation
Zebrafish frizzled-2 morphant displays defects in body axis elongation
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DOI：
10.1002/gene.1043
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发表时间：
2001-07-01
期刊：
影响因子：
1.5
通讯作者：
Ekker, SC
中科院分区：
文献类型：
--
作者：
Sumanas, S;Kim, HJ;Ekker, SC
描述了斑马鱼（Danio rerio）跨膜Wnt受体卷曲-2（fz2）的第一个特异性功能丧失表型。观察到的轴向结构的波动，以及在原肠形成过程中观察到的胚胎形状的变化，表明fz2可能通过控制收敛伸展运动参与了原肠形成过程。此外，研究结果表明，wnt5和fz2可能在原肠胚形成和轴伸长过程中发挥相同的信号通路。
The first specific loss-of-function phenotype for a transmembrane Wnt receptorfrizzled-2(fz2) in zebrafish (Danio rerio) is described. The observed undulations of axial structures, together with the observed changes in embryo shape during gastrulation, argue for the involvement of fz2 in the process of gastrulation, possibly through the control of convergent extension movements. Moreover, the results suggest that wnt5 and fz2 may function in the same signalling pathway during gastrulation and axis elongation.