Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease.
Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease.
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DOI：
10.1016/j.neuint.2008.10.008
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发表时间：
2009-02
影响因子：
4.2
通讯作者：
Gibson, Gary E.
中科院分区：
文献类型：
--
作者：
Karuppagounder, Saravanan S.;Pinto, John T.;Xu, Hui;Chen, Huan-Lian;Beal, M. Flint;Gibson, Gary E.
白藜芦醇是一种存在于红酒、花生、大豆和棕榈酸酯中的多酚，具有广泛的生物学效应。由于白藜芦醇的特性似乎是治疗神经退行性疾病的理想选择，因此对其减少淀粉样斑块的能力进行了测试。小鼠被喂食临床可行剂量的白藜芦醇45天。白藜芦醇及其结合代谢产物在脑中均未检测到。然而，白藜芦醇减少斑块形成的区域特异性的方式。斑块所占面积百分比的最大降幅出现在内侧皮质（-48%）、纹状体（-89%）和下丘脑（-90%）。这些变化发生时没有可检测到的SIRT-1激活或APP加工的改变。然而，大脑谷胱甘肽下降21%，大脑半胱氨酸增加54%。半胱氨酸增加和谷胱甘肽减少可能与斑块形成减少有关。这项研究支持了这样一种观点，即使用饮食化学预防剂可以延迟或减轻神经退行性疾病的发作，这些药物可以防止β-淀粉样蛋白诱导的神经元损伤。
Resveratrol, a polyphenol found in red wine, peanuts, soy beans, and pomegranates, possesses a wide range of biological effects. Since resveratrol’s properties seem ideal for treating neurodegenerative diseases, its ability to diminish amyloid plaques was tested. Mice were fed clinically feasible dosages of resveratrol for forty-five days. Neither resveratrol nor its conjugated metabolites were detectable in brain. Nevertheless, resveratrol diminished plaque formation in a region specific manner. The largest reductions in the percent area occupied by plaques were observed in medial cortex (−48%), striatum (−89%) and hypothalamus (−90%). The changes occurred without detectable activation of SIRT-1 or alterations in APP processing. However, brain glutathione declined 21% and brain cysteine increased 54%. The increased cysteine and decreased glutathione may be linked to the diminished plaque formation. This study supports the concept that onset of neurodegenerative disease may be delayed or mitigated with use of dietary chemo-preventive agents that protect against β-amyloid induced neuronal damage.
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影响因子：
6.1
作者：
Frémont, L;Belguendouz, L;Delpal, S
通讯作者：
Delpal, S
影响因子：
4.1
作者：
HALLMAN, PS;PERRIN, DD;WATT, AE
通讯作者：
WATT, AE
影响因子：
11.4
作者：
Kim, Dohoon;Nguyen, Minh Dang;Tsai, Li-Huei
通讯作者：
Tsai, Li-Huei
DOI：
10.1073/pnas.0610068104
发表时间：
2007-04-24
影响因子：
11.1
作者：
Dasgupta, Biplab;Milbrandt, Jeffrey
通讯作者：
Milbrandt, Jeffrey
影响因子：
4.2
作者：
Karuppagounder, Saravanan S.;Xu, Hui;Gibson, Guy E.
通讯作者：
Gibson, Guy E.