A model for central synaptic junctional complex formation based on the differential adhesive specificities of the cadherins
A model for central synaptic junctional complex formation based on the differential adhesive specificities of the cadherins
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DOI：
10.1016/s0896-6273(00)80175-0
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发表时间：
1996-09-01
期刊：
影响因子：
16.2
通讯作者：
Colman, DR
中科院分区：
文献类型：
--
作者：
Fannon, AM;Colman, DR
钙粘蛋白通过有据可查的血友病相互作用控制关键的发育事件。在上皮中，它们是介导细胞间粘附的连接的标志成分。脑组织表达几种钙粘蛋白，我们现在发现其中两种，神经（N）和上皮（E）-钙粘蛋白，定位于突触复合体中相互排斥的分布。在小脑中，N-钙粘蛋白经常与突触相关，其中一些是穿孔的，在海马中，发现含有N-和E-钙粘蛋白的突触沿着CA 3透明层内的树突轴排列。我们认为钙粘蛋白在突触复合体的突触前膜和突触后膜之间起主要的粘附作用。根据这个模型，一旦神经突被引导到它们的同源靶点附近，则是钙粘蛋白沿着轴突和树突质膜的差异分布，以及最终的钙粘蛋白自缔合，“锁定”新生的突触连接。
Cadherins control critical developmental events through well-documented hemophilic interactions. In epithelia, they are hallmark constituents of junctions that mediate intercellular adhesion. Brain tissue expresses several cadherins, and we now show that two of these, neural (N)- and epithelial (E)-cadherin, are localized to synaptic complexes in mutually exclusive distributions. In cerebellum, N-cadherin is frequently found associated with synapses, some of which are perforated, and in hippocampus, N- and E-cadherin-containing synapses are found aligned along dendritic shafts within the stratum lucidum of CA3. We propose that the cadherins function as primary adhesive moieties between pre- and postsynaptic membranes in the synaptic complex. According to this model, once neurites have been guided to the vicinity of their cognate targets, it is the differential distribution of cadherins along the axonal and dendritic plasma membranes, and ultimately cadherin self-association, that "locks in" nascent synaptic connections.