A genome-wide scan for body mass index among Nigerian families
A genome-wide scan for body mass index among Nigerian families
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DOI：
10.1038/oby.2003.40
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发表时间：
2003-02-01
期刊：
影响因子：
--
通讯作者：
Ward, R
中科院分区：
文献类型：
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作者：
Adeyemo, A;Luke, A;Ward, R
目的：由于肥胖及其并发症在世界范围内的流行率不断增加，对与肥胖相关的遗传变异作图的兴趣仍然很高。在非洲population.Research方法和程序的肥胖的遗传决定因素的数据是罕见的：我们已经进行了全基因组扫描的身体质量指数（BMI）在182个尼日利亚家庭，包括769 individuals.Results：肥胖的患病率只有5%，但BMI的多基因遗传力在预期范围内（0.46 +/- 0.07）。在基因组中对串联重复标记（402）进行分型，平均图谱密度为9 cM。使用方差分量连锁模型进行的基于谱系的分析证明了7号染色体（7 p14处标记D 7S 817附近）上的连锁证据，其比值对数（LOD）评分为3.8，11号染色体（11 q22处标记D11 S2000）上的LOD评分为3.3。在1号染色体（1 q21，LOD = 2.2）和8号染色体（8 p22，LOD = 2.3）上发现了较弱的连锁证据。几个候选基因，包括神经肽Y，DRD 2，载脂蛋白A4，核纤层蛋白A/C，脂蛋白脂肪酶，位于或接近的染色体区域，其中强连锁signals.Discussion：这项研究的结果表明，在其他人群中具有较高的患病率肥胖，积极的连锁信号，可以发现对基因组扫描肥胖相关性状。后续研究可能需要调查这些联系，特别是11号染色体上的联系，这在BMI分布的另一端人群中已有报道。
Objective: Interest in mapping genetic variants that are associated with obesity remains high because of the increasing prevalence of obesity and its complications worldwide. Data on genetic determinants of obesity in African populations are rare.Research Methods and Procedures: We have undertaken a genome-wide scan for body mass index (BMI) in 182 Nigerian families that included 769 individuals.Results: The prevalence of obesity was only 5%, yet polygenic heritability for BMI was in the expected range (0.46 +/- 0.07). Tandem repeat markers (402) were typed across the genome with an average map density of 9 cM. Pedigree-based analysis using a variance components linkage model demonstrated evidence for linkage on chromosome 7 (near marker D7S817 at 7p14) with a logarithm of odds (LOD) score of 3.8 and on chromosome 11 (marker D11S2000 at 11q22) with an LOD score of 3.3. Weaker evidence for linkage was found on chromosomes 1 (1q21, LOD = 2.2) and 8 (8p22, LOD = 2.3). Several candidate genes, including neuropeptide Y, DRD2, APOA4, lamin A/C, and lipoprotein lipase, lie in or close to the chromosomal regions where strong linkage signals were found.Discussion: The findings of this study suggest that, as in other populations with higher prevalences of obesity, positive linkage signals can be found on genome scans for obesity-related traits. Follow-up studies may be warranted to investigate these linkages, especially the one on chromosome 11, which has been reported in a population at the opposite end of the BMI distribution.